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  4. Mouse cluster of differentiation 6(CD6) ELISA Kit

Mouse cluster of differentiation 6(CD6) ELISA Kit

  • 中文名稱：
    小鼠CD6分子酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL004949MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠CD6分子酶聯(lián)免疫試劑盒（CSB-EL004949MO）檢測樣本中的CD6含量。CD6是一種在T淋巴細胞等免疫細胞上表達的細胞表面蛋白質(zhì)，由人類基因CD6編碼。它在胸腺細胞發(fā)育、T細胞活化和免疫反應中起關鍵作用，與T細胞受體（TCR）/CD3復合物在免疫突觸中心物理相關聯(lián)。CD6的研究涉及其在自身免疫性疾病中的作用，如多發(fā)性硬化癥和類風濕性關節(jié)炎，以及作為治療靶點的潛力。支持科研人員開展免疫細胞功能研究、疾病模型構建、藥物干預效果評估等實驗，為免疫學基礎研究及轉化醫(yī)學提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cd6T-cell differentiation antigen CD6 ELISA Kit; CD antigen CD6 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 檢測范圍：
    Request Information
  • 靈敏度：
    Request Information
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
  • 基因功能參考文獻：
    1. Results indicate Cdcp1 (CD318) as a ligand of T-cell differentiation antigen CD6 (CD6) and a potential target for the diagnosis and treatment of autoimmune diseases. PMID: 28760953
    2. These results suggest that (i) CD6 is a negative regulator of T-cell activation, (ii) at the same time, CD6 is a positive regulator of activated T-cell survival/proliferation and infiltration; and (iii) CD6 is a potential new target for treating multiple sclerosis (MS)and potentially other T-cell-driven autoimmune conditions. PMID: 28209777
    3. these data indicate that CD6 modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg cells PMID: 27377588
    4. results reveal an unexpected role of CD6 in the pathogenesis of intestinal IR-induced injury by regulating the self-renewal of B1a cells. PMID: 27909060
    5. this analysis identified 65 proteins not associated before with the Zap70-Lat-SLP-76 network and thus should provide cues for future functional experiments. PMID: 24584089

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed predominantly in thymus, lymph node and spleen.
  • 數(shù)據(jù)庫鏈接：