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  4. Rat low density lipoprotein receptor,LDLR ELISA Kit

Rat low density lipoprotein receptor,LDLR ELISA Kit

  • 中文名稱：
    大鼠低密度脂蛋白受體(LDLR)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13545r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠低密度脂蛋白受體(LDLR)酶聯(lián)免疫試劑盒（CSB-E13545r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的LDLR含量。LDLR（低密度脂蛋白受體）是一種在細(xì)胞膜上存在的蛋白質(zhì)，主要功能是降解血液中的低密度脂蛋白（LDL），從而維持膽固醇的穩(wěn)態(tài)。LDLR的表達(dá)和功能受到多種因素的調(diào)節(jié)，包括膽固醇水平、胰島素、甲狀腺激素等。LDLR缺陷或功能障礙與多種疾病，如家族性高膽固醇血癥和動脈粥樣硬化有關(guān)。研究LDLR的機制有助于開發(fā)新的治療策略來預(yù)防和治療這些疾病。試劑盒檢測范圍為7.8 pg/mL-500 pg/mL，適用于基礎(chǔ)科研中探究高膽固醇飲食模型、心血管疾病動物模型的LDLR動態(tài)變化，以及藥物干預(yù)對脂質(zhì)代謝通路影響的機制研究。適用于肝臟、血管等組織樣本與體液樣本的平行檢測，為脂質(zhì)代謝相關(guān)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ldlr ELISA Kit; Low-density lipoprotein receptor ELISA Kit; LDL receptor ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    7.8 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat LDLR in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:200 Average % 85
    Range % 80-89
    1:400 Average % 102
    Range % 98-108
    1:800 Average % 90
    Range % 85-94
    1:1600 Average % 97
    Range % 92-101
  • 回收率：
    The recovery of rat LDLR spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 88 84-92
    EDTA plasma (n=4) 93 89-100
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    500 2.512 2.475 2.494 2.355
    250 2.247 2.196 2.222 2.083
    125 1.803 1.689 1.746 1.607
    62.5 1.189 1.227 1.208 1.069
    31.2 0.687 0.713 0.700 0.561
    15.6 0.415 0.392 0.404 0.265
    7.8 0.298 0.289 0.294 0.155
    0 0.136 0.141 0.139 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
  • 基因功能參考文獻(xiàn)：
    1. LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the peptide vectors we developed have the potential to transport drugs PMID: 28108572
    2. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol accumulation via increased LDL cholesterol uptake into the liver with resulting persistent increases in hepatic cholesterol accumulation. PMID: 27401460
    3. Compared with the cholesterol-enriched restructured pork group, silicon-enriched restructured pork rats had lower VLDL compound concentrations and lower VLDL oxidation but greater Ldlr expression. PMID: 26246324
    4. The LDL receptor could be located at once in clathrin-coated pits and caveolae. PMID: 24530906
    5. LDLR mutant rats are a useful novel animal model of hypercholesterolemia and atherosclerosis. PMID: 22293196
    6. A tissue-specific dysregulation of LDLr is demonstrated that is age- and gender-dependent. PMID: 21792919
    7. expression of LDLR was increased in the hippocampus of stroke-prone spontaneously hypertensive rats and was seen in the luminal and abluminal cytoplasmic membranes and vesicular structures of endothelial cells PMID: 20458492
    8. expression pattern of LDL-R in brain microvessels endothelial cells and its modulation by astrocytes PMID: 12095612
    9. cloning and sequencing of the rat LDL receptor 5'-flanking region revealed the presence of several putative cis-acting elements PMID: 16647292
    10. Retina is capable of rapid uptake of circulating LDL via LDLR-mediated process primarily occurring in retinal pigment epithelium and also possibly Muller cells. PMID: 17110914
    11. Caloric restriction affects Ldlr involved in age-related hypercholesterolemia. PMID: 17203467
    12. LDLR-mediated pathway was involved in the endocytosis of Poly(methoxypolyethyleneglycol cyanoacrylate-co-hexadecylcyanoacrylate) (PEG-PHDCA) nanoparticles by RBEC. PMID: 17256088
    13. Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats. PMID: 17674160

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome.
  • 蛋白家族：
    LDLR family
  • 數(shù)據(jù)庫鏈接：