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  4. TMEM192 Recombinant Monoclonal Antibody

TMEM192 Recombinant Monoclonal Antibody

  • 中文名稱：
    TMEM192重組抗體
  • 貨號：
    CSB-RA249639A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, PC-3 whole cell lysate, U251 whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
      All lanes: TMEM192 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 31 kDa
      Observed band size: 31 kDa
    • IHC image of CSB-RA249639A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA249639A0HU TMEM192重組單克隆抗體是針對跨膜蛋白192（TMEM192）研發(fā)的高特異性科研工具，適用于蛋白質(zhì)定位及功能機制研究。TMEM192作為溶酶體相關(guān)跨膜蛋白，在細胞器穩(wěn)態(tài)維持、物質(zhì)運輸及代謝調(diào)控中發(fā)揮重要作用。該抗體經(jīng)多種技術(shù)平臺驗證，在Western Blot（WB）中可識別天然狀態(tài)靶蛋白，呈現(xiàn)單一清晰條帶；免疫組化（IHC）實驗顯示其在多種組織樣本中能精準定位TMEM192的亞細胞分布，染色結(jié)果呈現(xiàn)優(yōu)異的分辨率和特異性。推薦使用稀釋度為WB 1:500-1:2000，IHC 1:50-1:200，實驗數(shù)據(jù)展現(xiàn)優(yōu)異的批次間穩(wěn)定性和重復性。本產(chǎn)品適用于探索溶酶體生物學功能、細胞器互作網(wǎng)絡(luò)分析、以及疾病模型中跨膜蛋白異常表達研究等領(lǐng)域，為細胞生物學、分子病理學及代謝調(diào)控機制等基礎(chǔ)研究提供可靠檢測工具，嚴格限于體外實驗及科學研究使用。
  • Uniprot No.：
  • 基因名：
    TMEM192
  • 別名：
    Transmembrane protein 192, TMEM192
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human TMEM192
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    21G8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. Authors found that transmembrane protein 192 (TMEM192) interacted with TIG1. Authors also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins. PMID: 27989102
    2. TMEM192 deficiency can induce autophagy in tumor cells, and can further activate apoptosis by the mitochondrial pathway through autophagy. PMID: 22736246
    3. TMEM192 was found to be strongly expressed in human kidney, liver, lung and pancreas tissue. The widespread tissue distribution could suggest an important role of TMEM192 for lysosomal function. PMID: 20370317
  • 亞細胞定位：
    Lysosome membrane; Multi-pass membrane protein. Late endosome.
  • 蛋白家族：
    TMEM192 family
  • 組織特異性：
    Strongly expressed in kidney, liver, lung and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26775

    KEGG: hsa:201931

    STRING: 9606.ENSP00000305069

    UniGene: Hs.704511