皮肌炎（DM）是一種累及皮膚和橫紋肌的自身免疫性結(jié)締組織病，通常呈現(xiàn)亞急性或慢性發(fā)病。其病因尚不明確，可能與自身免疫、感染、腫瘤及遺傳因素相關(guān)。成人皮肌炎的年發(fā)病率為（5-10/100 萬(wàn)，男女比例約1∶2，發(fā)病年齡呈現(xiàn)雙峰分布，即兒童期（5-15歲）和45-65歲的成年人高發(fā)。臨床上，皮肌炎主要表現(xiàn)為皮膚和肌肉受累癥狀，如特征性的Heliotrope征、Gottron丘疹，以及對(duì)稱性四肢近端肌群和頸部肌無(wú)力等，部分患者還可能伴發(fā)惡性腫瘤或出現(xiàn)間質(zhì)性肺病等并發(fā)癥 。?
近年來(lái)針對(duì)皮肌炎的新型藥物不斷涌現(xiàn)。生物制劑成為研發(fā)熱點(diǎn)之一，例如抗白細(xì)胞介素 - 6 受體拮抗劑等針對(duì)特定細(xì)胞因子或免疫通路的藥物，已顯示出一定治療潛力。以利妥昔單抗為例，在難治性青少年皮肌炎（JDM）治療中，對(duì)458例患者的臨床數(shù)據(jù)分析顯示，78.3%患者的皮膚和肌肉癥狀得到改善，且多數(shù)患者肌炎特異性自身抗體結(jié)果呈陽(yáng)性改變，癥狀未反復(fù) 。此外，小分子靶向藥物也在探索階段。在jak抑制劑中，托法替布是美國(guó)食品藥品監(jiān)督管理局（FDA）首個(gè)批準(zhǔn)用于治療自身免疫性疾病的該類(lèi)藥物，多個(gè)案例報(bào)告證實(shí)其對(duì)嚴(yán)重皮膚疾病和難治性DM患者有效，可改善皮膚疹、關(guān)節(jié)疼痛、肌肉力量，還能減少皮質(zhì)類(lèi)固醇治療需求。2025年2月，上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院風(fēng)濕科葉霜教授團(tuán)隊(duì)研究顯示，托法替布作為初始免疫抑制方案，對(duì)抗MDA5陽(yáng)性皮肌炎合并間質(zhì)性肺病患者的1年無(wú)肺移植生存獲益顯著高于鈣調(diào)磷酸酶抑制劑。
皮肌炎（DM）在研藥物靶點(diǎn)
皮肌炎（DM）藥物靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CD7
CSB-MP004953HU
CSB-MP004953HU
Measured by its binding ability in a functional ELISA. Immobilized CD7 at 5 μg/ml can bind SECTM1 (CSB-MP819898HU), the EC50 is 1.236-1.773 ng/ml.
GLP1R
CSB-MP009514HUb1
CSB-MP009514HUb1
Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC50 is 54.54-94.23 ng/mL.
IL6
CSB-EP011664HU
CSB-EP011664HU
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.1518 - 0.3987 ng/mL.
PDCD1
CSB-MP619964HU1
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
| Target | Product Name | Source | Tag Info | Code |
|---|---|---|---|---|
| C5 | Recombinant Human Complement C5 (C5), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP003995HU |
| C5 | Recombinant Rat Complement C5 (C5) | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP003995RA |
| C5 | Recombinant Human Complement C5 (C5), partial | Mammalian cell | N-terminal 6xHis-Myc-tagged | CSB-MP003995HU |
| C5 | Recombinant Pig Complement C5a anaphylatoxin (C5) | Yeast | N-terminal 6xHis-tagged | CSB-YP003995PI |
| CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial | in vitro E.coli expression system | N-terminal 6xHis-tagged | CSB-CF004888HU |
| CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial | in vitro E.coli expression system | C-terminal 6xHis-tagged | CSB-CF004888HUc7 |
| CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-MP004888HU |
| CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) | Mammalian cell | C-terminal Fc-tagged | CSB-AP005061HU |
| CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial, Biotinylated | Mammalian cell | C-terminal hFc1-Avi-tagged | CSB-MP004888HU-B |
| CD6 | Recombinant Human T-cell differentiation antigen CD6(CD6), partial | Yeast | C-terminal 6xHis-Myc-tagged | CSB-YP326953HU |
| CD6 | Recombinant Human T-cell differentiation antigen CD6(CD6), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP326953HUa0 |
| CD7 | Recombinant Human T-cell antigen CD7 (CD7), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP004953HU |
| CD7 | Recombinant Human T-cell antigen CD7 (CD7), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004953HU |
| CD7 | Recombinant Human T-cell antigen CD7 (CD7), partial (Active) | Mammalian cell | C-terminal hFc1-Myc-tagged | CSB-MP004953HU |
| CD7 | Recombinant Human T-cell antigen CD7 (CD7), partial | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-MP004953HUb1 |
| CD7 | Recombinant Human T-cell antigen CD7 (CD7), partial, Biotinylated | Mammalian cell | C-terminal mFc-Avi-tagged | CSB-MP004953HU-B |
| Cfb | Recombinant Mouse Complement factor B (Cfb) | E.coli | N-terminal 6xHis-tagged | CSB-EP005268MO |
| Cfb | Recombinant Mouse Complement factor B (Cfb) | Mammalian cell | C-terminal 10xHis-tagged | CSB-MP005268MO |
| Cfb | Recombinant Mouse Complement factor B (Cfb) | E.coli | C-terminal 6xHis-tagged | CSB-EP005268MOc7 |
| CGAS | Recombinant Human Cyclic GMP-AMP synthase (CGAS), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP822726HU |
● 抗體
C5 Recombinant Monoclonal Antibody
CSB-RA003995MA1HU
CSB-RA003995MA1HU
Tested Applications:
ELISA, FC
CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU
CSB-RA780821A0HU
Tested Applications:
ELISA, WB, IHC, IP
Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody
CSB-RA011931A100phHU
CSB-RA011931A100phHU
Tested Applications:
ELISA, WB, IHC, IP
PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU
CSB-RA240597A0HU
Tested Applications:
ELISA, WB, IHC
- 重組抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| C5 | C5 Recombinant Monoclonal Antibody | Human | ELISA, FC | CSB-RA003995MA1HU |
| CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA004888A0HU |
| CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP | CSB-RA780821A0HU |
| CD19 | CD19 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB | CSB-RA004888MA1HU |
| GLP1R | GLP1R Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA009514MA1HU |
| IFNAR1 | IFNAR1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA011046A0HU |
| IL23A | IL23A Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA251959A0HU |
| JAK1 | JAK1 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA227790A0HU |
| JAK2 | Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP | CSB-RA011931A100phHU |
| JAK2 | JAK2 Recombinant Monoclonal Antibody | Human | ELISA, IF | CSB-RA267127A0HU |
| JAK3 | JAK3 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA206737A0HU |
| LTA | LTA Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA013218A0HU |
| MS4A1 | CD20 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A0HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A1HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA | CSB-RA015007MA3HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF | CSB-RA015007MA4HU |
| NR3C1 | NR3C1 Recombinant Monoclonal Antibody | Human | ELISA, WB, FC | CSB-RA958910A0HU |
| PDCD1 | PDCD1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA240597A0HU |
| S1PR1 | S1PR1 Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA923827A0HU |
| TLR7 | TLR7 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA556665A0HU |
- 單克隆抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| CD19 | CD19 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC | CSB-MA004888A0m |
| CD19 | CD19 Monoclonal Antibody | Human | ELISA, WB, IHC, FC | CSB-MA004888A1m |
| CD19 | CD19 Monoclonal Antibody,APC Conjugated | Human | ELISA, IF, FC | CSB-MA195220 |
| CD19 | CD19 Monoclonal Antibody,Biotin Conjugated | Human | ELISA, IF, FC | CSB-MA899608 |
| CD19 | CD19 Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA047662 |
| CD19 | CD19 Monoclonal Antibody,PE Conjugated | Human | ELISA, IF, FC | CSB-MA036486 |
| CD19 | CD19 Monoclonal Antibody,PE-Cy5 Conjugated | Human | ELISA, IF, FC | CSB-MA281869 |
| CD19 | CD19 Monoclonal Antibody,Purified | Human | ELISA, FC | CSB-MA798261 |
| JAK1 | JAK1 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA919964 |
| JAK2 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA181103 |
| JAK2 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA780030 |
| MS4A1 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000204 |
| MS4A1 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA996413 |
| TNF | TNF Monoclonal Antibody | Bovine | ELISA | CSB-MA084771A0m |
| TNF | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA, WB, IHC | CSB-MA080271 |
| TNF | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA, WB, IHC | CSB-MA080272 |
| TNFRSF17 | TNFRSF17 Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-MA023974A0m |
| TNFRSF17 | TNFRSF17 Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-MA023974A1m |
- 多克隆抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| C5 | C5 Antibody | Human | ELISA, IHC | CSB-PA003995LA01HU |
| C5 | C5 Antibody | Pig | ELISA, IHC | CSB-PA003995YA01PI |
| CD19 | CD19 Antibody | Human, Mouse, Monkey | ELISA, WB | CSB-PA001431 |
| CD19 | Phospho-CD19 (Y531) Antibody | Human, Mouse, Monkey | ELISA, WB | CSB-PA070286 |
| CD19 | CD19 Antibody | Human | ELISA, WB | CSB-PA006159 |
| CD19 | CD19 (Ab-531) Antibody | Human, Mouse | ELISA, WB | CSB-PA253616 |
| CD19 | Phospho-CD19 (Tyr531) Antibody | Human, Mouse | ELISA, WB | CSB-PA058389 |
| CD6 | CD6 Antibody | Human | ELISA, WB, IHC | CSB-PA326953ESR1HU |
| CD6 | CD6 Antibody | Human | ELISA, IHC | CSB-PA326953ESR2HU |
| CD6 | CD6 Antibody | Human | ELISA, WB | CSB-PA006156 |
| CD6 | CD6 Antibody | Human | ELISA, WB | CSB-PA070265 |
| CD6 | CD6 Antibody | Human | ELISA, WB | CSB-PA134350 |
| CD7 | CD7 Antibody | Human | ELISA, IHC | CSB-PA004953YA01HU |
| CD7 | CD7 Antibody | Human | ELISA, IHC | CSB-PA004953ESR1HU |
| CD7 | CD7 Antibody | Human | ELISA, WB | CSB-PA005197 |
| CFB | CFB Antibody | Human | ELISA, WB, IHC | CSB-PA11049A0Rb |
| Cfb | Cfb Antibody | Mouse, Human | ELISA, WB | CSB-PA005268LA01MO |
| CFB | Cleaved-CFB (K260) Antibody | Human, Mouse | ELISA, WB | CSB-PA040288 |
| CFB | CFB Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA005268GA01HU |
| CNR2 | CNR2 Antibody | Human | ELISA, IHC, IF | CSB-PA005679LA01HU |
● ELISA試劑盒
Rat TNF-α ELISA kit
CSB-E11987r
Mouse Interferon β,IFN-β/IFNB ELISA Kit
CSB-E04945m
Bovine Interleukin 12,IL-12 ELISA Kit
CSB-E14010B
| Target | Product Name | Sample Types | Detection Range | Code |
|---|---|---|---|---|
| TNF | Rat TNF-α ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 6.25 pg/mL-400 pg/mL | CSB-E11987r |
| TNF | Mouse Tumor necrosis factor α,TNF-α ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates | 15.6 pg/ml-1000 pg/ml | CSB-E04741m |
| TNF | Human Tumor necrosis factor α,TNF-α ELISA KIT | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 7.8 pg/mL-500 pg/mL | CSB-E04740h |
| TNF | Bovine TNF-αELISA kit | serum, plasma, tissue homogenates | 0.1 ng/mL-20 ng/mL | CSB-E12020B |
| TNF | Rabbit Tumor necrosis factor α,TNFα ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 78 pg/mL-5000 pg/mL | CSB-E06998Rb |
| IFNB1 | Mouse Interferon β,IFN-β/IFNB ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 15.6 pg/mL-1000 pg/mL | CSB-E04945m |
| IFNB1 | Human Interferon β,IFN-β/IFNB ELISA Kit | serum, urine, cell culture supernates, tissue homogenates, cerebrospinal fluid (CSF) | 31.25 pg/mL-2000 pg/mL | CSB-E09889h |
| TNF | Pig Tumor necrosis factor (TNF/TNFA/TNFSF2) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.047 ng/mL-3 ng/mL | CSB-E16980p |
| TNF | Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit | serum, plasma, tissue homogenates | 3.12 pg/mL-200 pg/mL | CSB-E06772Gu |
| TNF | Sheep Tumor Necrosis Factor α,TNF-α ELISA Kit | serum, plasma, tissue homogenates | 3.125 pg/mL-50 pg/mL | CSB-E13853Sh |
| TNF | Goat Tumor necrosis factor α,TNF-α ELISA KIT | serum, plasma, tissue homogenates | 15.6 pg/mL-1000 pg/mL | CSB-E09811g |
| LTA | Mouse Tumor necrosis factor β,TNF-β ELISA KIT | serum, plasma, tissue homogenates | 18.75 pg/mL-1200 pg/mL | CSB-E04744m |
| IL12A | Bovine Interleukin 12,IL-12 ELISA Kit | serum, plasma, tissue homogenates | 6.25 pg/mL-400 pg/mL | CSB-E14010B |
| PDCD1 | Human Programmed Death 1(PD-1)ELISA KIT | serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL-1000 pg/mL | CSB-E13643h |
| NR3C1 | Rat glucocorticoid receptor,GR ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 15.6 pg/mL-1000 pg/mL | CSB-E08747r |
| LTA | Human Tumor necrosis factor β,TNF-β ELISA KIT | serum, plasma, cell culture supernates | 15.6 pg/mL-1000 pg/mL | CSB-E04743h |
| IFNB1 | Rat Interferon β,IFN-β/IFNB ELISA Kit | serum, plasma, tissue homogenates | 15.6 pg/mL-1000 pg/mL | CSB-E04845r |
| IFNB1 | Bovine Interferon β,IFN-β/IFNB ELISA Kit | Request Information | CSB-E13699B | |
| TNF | Horse Tumor necrosis factor α,TNF-α ELISA Kit | serum, plasma, tissue homogenates | 15.6 pg/mL-1000 pg/mL | CSB-E14031Hs |
| CFB | Human factor B,BF ELISA Kit | serum, plasma | 1.56 ng/mL-100 ng/mL | CSB-E09447h |
