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間質(zhì)性肺疾?。↖LD）是一組以肺實(shí)質(zhì)炎癥和進(jìn)行性纖維化為特征的異質(zhì)性疾病，核心病理機(jī)制為肺泡上皮反復(fù)損傷后異常修復(fù)，導(dǎo)致成纖維細(xì)胞活化、細(xì)胞外基質(zhì)（如膠原）過(guò)度沉積，形成不可逆的肺瘢痕。

ILD包含200余種亞型，其中特發(fā)性肺纖維化（IPF）最常見(jiàn)且預(yù)后最差，主要影響50歲以上人群，全球患病率約6.3/10萬(wàn)，5年生存率僅20%-25%，低于多數(shù)癌癥。臨床表現(xiàn)為進(jìn)行性呼吸困難、干咳、爆裂音，晚期可繼發(fā)肺動(dòng)脈高壓和呼吸衰竭。

近年ILD藥物研發(fā)聚焦抗纖維化新靶點(diǎn)與疾病修飾療法，最新進(jìn)展如下：

► PDE4B抑制劑：

那米司特（Nerandomilast）：勃林格殷格翰的口服選擇性PDE4B抑制劑，通過(guò)升高細(xì)胞內(nèi)cAMP抑制NF-κB/NFAT信號(hào)，減少促炎因子釋放。2025年2月其III期研究FIBRONEER?-ILD達(dá)到主要終點(diǎn)，成為十年來(lái)首個(gè)成功的III期新藥，已向中美監(jiān)管機(jī)構(gòu)遞交IPF和進(jìn)展性肺纖維化（PPF）適應(yīng)癥申請(qǐng)。
SYH2059：石藥集團(tuán)的高選擇性PDE4B抑制劑，臨床前活性優(yōu)于同類藥物，2025年獲中美臨床試驗(yàn)批準(zhǔn)，靶向ILD。

► 細(xì)胞療法：

NCR101注射液：全球首款iPSC來(lái)源的基因修飾間充質(zhì)樣細(xì)胞（iMSC）療法，通過(guò)基因工程增強(qiáng)抗炎與組織修復(fù)功能。2025年3月獲中國(guó)臨床許可，治療ILD，突破傳統(tǒng)MSC的異質(zhì)性與產(chǎn)量限制。

► 急性加重期治療優(yōu)化：

尼達(dá)尼布：系統(tǒng)評(píng)價(jià)顯示，在ILD急性加重期（AE-ILD）啟動(dòng)治療可顯著降低住院死亡率并縮短住院時(shí)間，可能與多重酪氨酸激酶抑制（PDGFR/VEGFR/FGFR）阻斷纖維化信號(hào)相關(guān)。

► 其他新興靶點(diǎn)：

WISP1抗體（MTX-463）：禮來(lái)/Mediar開(kāi)發(fā)，中和WNT通路關(guān)鍵蛋白WISP1，阻斷成纖維細(xì)胞活化，II期試驗(yàn)進(jìn)行中。
JAK抑制劑（如魯索替尼）：靶向JAK-STAT通路調(diào)控巨噬細(xì)胞極化，臨床前使膠原沉積減少50%，探索老藥新用。

間質(zhì)性肺疾病（ILD）在研藥物靶點(diǎn)

間質(zhì)性肺疾?。↖LD）藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

BSG
CSB-MP002831HU1

Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC₅₀ is 21.95-33.12 ng/ml.

CCN2
CSB-MP5112MOW

Measured by its binding ability in a functional ELISA. Immobilized Rhesus macaque CTGF at 1 μg/ml can bind Anti-CTGF recombinant antibody (CSB-RA006147MA2HU). The EC₅₀ is 0.6886-0.7825 ng/mL.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m,antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL.

CSF1
CSB-MP006043HU1

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.

IL13
CSB-MP6408HU

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 2.045-6.215 ng/mL

PDCD1
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL.

NT5E
CSB-MP723415HU

Measured by its binding ability in a functional ELISA. Immobilized CD73 at 2 μg/ml can bind Anti- CD73 Rabbit Monoclonal Antibody (CSB-RA978310A0HU), the EC₅₀ is 3.212-4.525 ng/ml.

TSLP
CSB-MP025141HUh7

Measured by its binding ability in a functional ELISA.Immobilized Human TSLP at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC₅₀ is 5.487-6.214 ng/mL.

Target	Product Name	Source	Tag Info	Code
B2M	Recombinant Sheep Beta-2-microglobulin (B2M)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP002486SH
B2M	Recombinant Pig Beta-2-microglobulin (B2M)	E.coli	Tag-free	CSB-EP4852PI
B2m	Recombinant Mesocricetus auratus Beta-2-microglobulin (B2m)	E.coli	Tag-Free	CSB-EP4853MRG
BSG	Recombinant Human Basigin (BSG), partial (Active)	Mammalian cell	C-terminal hFc-tagged	CSB-MP002831HU1
C5	Recombinant Human Complement C5 (C5), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003995HU
C5	Recombinant Rat Complement C5 (C5)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP003995RA
C5	Recombinant Human Complement C5 (C5), partial	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP003995HU
C5	Recombinant Pig Complement C5a anaphylatoxin (C5)	Yeast	N-terminal 6xHis-tagged	CSB-YP003995PI
CCL2	Recombinant Human C-C motif chemokine 2 protein (CCL2)	E.coli	N-terminal GST-tagged	CSB-EP004783HU
CCL2	Recombinant Human C-C motif chemokine 2 (CCL2)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP004783HUb1
CCL2	Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP004783MO
CCN2	Recombinant Human CCN family member 2 (CCN2)	E.coli	C-terminal 6xHis-tagged	CSB-EP006147HU
CCN2	Recombinant Human CCN family member 2 (CCN2), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP006147HU1
Ccn2	Recombinant Mouse CCN family member 2 (Ccn2), partial	E.coli	N-terminal 10xHis-SUMO-tagged	CSB-EP006147MO
Ccn2	Recombinant Mouse CCN family member 2 (Ccn2), partial	E.coli	N-terminal GST-tagged	CSB-EP006147MOe0
CCN2	Recombinant Macaca mulatta CCN family member 2 (CCN2)	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP5112MOW
Ccn4	Recombinant Rat CCN family member 4 (Ccn4), Biotinylated	E.coli	N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged	CSB-EP857523RA-B
CCR7	Recombinant Human C-C chemokine receptor type 7 (CCR7), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP004846HU1
CD274	Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP878942HU2
CD274	Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	Mammalian cell	C-terminal hFc-tagged	CSB-MP878942HU1

● 抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA977797A0HU

Tested Applications:
ELISA, WB, IHC

ITGAV Recombinant Monoclonal Antibody
CSB-RA279866A0HU

Tested Applications:
ELISA, WB, IHC

LOXL2 Recombinant Monoclonal Antibody
CSB-RA907007A0HU

Tested Applications:
ELISA, WB, IHC, IF, FC

NT5E Recombinant Monoclonal Antibody
CSB-RA978310A0HU

Tested Applications:
ELISA, IHC

- 重組抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
CD274	CD274 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA977797A0HU
CD274	CD274 Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC	CSB-RA878942MA1HU
CXCR4	CXCR4 Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA569311A0HU
CXCR4	CXCR4 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA006254MA01HU
IL6	IL6 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011664MA1HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA548303A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA279866A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA011877MA1HU
LOXL2	LOXL2 Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB, IHC, IF, FC	CSB-RA907007A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
NT5E	NT5E Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA978310A0HU
TSLP	TSLP Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA025141A1HU

- 單克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
CCL2	CCL2 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA058641A0m
ENG	ENG Monoclonal Antibody	Human	ELISA, IHC	CSB-MA294403
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IHC, IF, FC, IP	CSB-MA007670A0m
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IF, FC, IP	CSB-MA007670A1m
IL6	IL6 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA067571A0m
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272

- 多克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
B2M	B2M Monoclonal Antibody	Human	ELISA, IHC	CSB-MA057861A0m
CCL2	CCL2 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA058641A0m
ENG	ENG Monoclonal Antibody	Human	ELISA, IHC	CSB-MA294403
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IHC, IF, FC, IP	CSB-MA007670A0m
ENO1	ENO1 Monoclonal Antibody	Human, Mouse, Rat, Rabbit	ELISA, WB, IF, FC, IP	CSB-MA007670A1m
IL6	IL6 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA067571A0m
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272
AREG	AREG Antibody	Human	ELISA, IHC, IF	CSB-PA11339A0Rb
AREG	AREG Antibody	Human	ELISA, WB	CSB-PA006314
AREG	AREG Antibody	Human	ELISA, WB, IHC, IF	CSB-PA001986GA01HU
AREG	AREG Antibody	Human	ELISA, WB	CSB-PA441346
AREG	AREG Antibody	Human	ELISA, WB	CSB-PA694774
B2M	B2M Antibody	Human, Mouse	ELISA, WB, IHC	CSB-PA002486YA01HU
B2M	B2M Antibody	Human, Mouse	ELISA, WB	CSB-PA05786A0Rb
B2m	B2m Antibody	Mouse	ELISA, WB, IHC	CSB-PA002486LA01MO
B2M	B2M Antibody	Human, Mouse, Rat	ELISA, FC, IF, IHC, WB	CSB-PA002486GA01HU

● ELISA試劑盒

Mouse Tumor necrosis factor α,TNF-α ELISA KIT
CSB-E04741m

Mouse Interleukin 6,IL-6 ELISA KIT
CSB-E04639m

Mouse Transforming Growth factor β1,TGF-β1 ELISA kit
CSB-E04726m

Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit
CSB-E07430m

Target	Product Name	Sample Types	Detection Range	Code
CSF2	Human Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04568h
IL6	Human Interleukin 6,IL-6 ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, urine	7.8 pg/mL-500 pg/mL	CSB-E04638h
CCL2	Human monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tis	6.25 pg/ml-400 pg/ml.	CSB-E04655h
CSF1	Mouse Macrophage Colony-Stimulating Factor,M-CSF ELISA kit	serum, plasma, tissue homogenates	7.81 pg/mL-500 pg/mL	CSB-E04659m
TGFB1	Human Transforming Growth factor β1,TGF-β1 ELISA kit	serum, plasma, cell culture supernates	0.78 ng/mL-50 ng/mL	CSB-E04725h
TGFB1	Dog Transforming growth factor β1,TGF-β1 ELISA Kit	serum, plasma	0.781 ng/ml - 50 ng/ml	CSB-E04796c
B2M	Human β2-microglobulin,BMG/β2-MG ELISA Kit	serum, urine	0.039 μg/mL-10 μg/mL	CSB-E04883h
CCL2	Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit	serum, plasma, tissue homogenates	78 pg/mL-5000 pg/mL	CSB-E07430m
ENG	Mouse Soluble Endoglin,ENG/sCD105 ELISA Kit	serum, plasma, tissue homogenates	6.25 ng/mL-400 ng/mL	CSB-E09921m
CSF1R	Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E10012h
ENG	Human Soluble Endoglin,sENG/sCD105 ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E10030h
CCL2	Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit	serum, plasma, tissue homogenates	0.125 ng/mL-8 ng/mL	CSB-E15747c
IL6R	Human Interleukin 6 receptor(IL-6R)ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E16524h
TNF	Pig Tumor necrosis factor (TNF/TNFA/TNFSF2) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.047 ng/mL-3 ng/mL	CSB-E16980p
IL6	Mouse Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates	3.9 pg/ml-250 pg/ml	CSB-E04639m-IS
TNF	Mouse Tumor necrosis factor α,TNF-α ELISA KIT	q	62.5 pg/mL-4000 pg/mL	CSB-E04741m(1)
TNF	Mouse Tumor necrosis factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates, cell culture supernates	7.8 pg/ml-500 pg/ml	CSB-E04741m-IS
AREG	Human keratinocyte autocrine factor/Amphiregulin,KAF/AR ELISA Kit	serum, plasma	4.7 pg/mL-300 pg/mL	CSB-E04496h
CSF2	Mouse Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04569m
CSF2	Rat Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/ml - 1000 pg/ml	CSB-E04570r