欧美最猛性xxxx,色婷婷综合缴情综在线播放

重癥肌無力（Myasthenia Gravis, MG）是一種罕見的慢性自身免疫性神經(jīng)肌肉疾病，由致病性免疫球蛋白G（IgG）抗體攻擊神經(jīng)肌肉接頭突觸后成分（如乙酰膽堿受體AChR、肌肉特異性酪氨酸激酶MuSK等）引發(fā)，導(dǎo)致神經(jīng)信號(hào)傳遞障礙，臨床表現(xiàn)為波動(dòng)性肌無力和易疲勞性，常累及眼肌、延髓肌及肢體肌肉，嚴(yán)重時(shí)可致呼吸衰竭。約85%的患者為全身型（gMG），其中AChR抗體陽性占主導(dǎo)（80%），MuSK抗體陽性者癥狀更重。該病發(fā)病機(jī)制涉及抗體介導(dǎo)的補(bǔ)體激活（如C5介導(dǎo)膜攻擊復(fù)合物形成）及FcRn受體對(duì)致病性IgG的再循環(huán)維持，導(dǎo)致持續(xù)自身免疫損傷。

重癥肌無力（MG）的藥物研發(fā)進(jìn)展近年來聚焦于靶向致病抗體清除和補(bǔ)體通路調(diào)控兩大核心機(jī)制，形成了以FcRn抑制劑和補(bǔ)體C5抑制劑為主流的治療格局：

● FcRn靶點(diǎn)藥物通過阻斷FcRn-IgG結(jié)合加速致病抗體降解，成為當(dāng)前最活躍的研發(fā)方向。代表藥物包括艾加莫德（efgartigimod，全球首款FcRn抑制劑）、羅澤利昔珠單抗（rozanolixizumab，2025年3月國(guó)內(nèi)獲批）、尼卡利單抗（nipocalimab，2025年4月FDA獲批）等。

● 補(bǔ)體C5抑制劑則通過阻斷補(bǔ)體級(jí)聯(lián)末端減少膜攻擊復(fù)合物形成，代表藥物為瑞利珠單抗（ravulizumab，2025年4月國(guó)內(nèi)獲批）。

未來重癥肌無力（MG）的藥物將從廣譜免疫抑制向精準(zhǔn)靶向演進(jìn)，F(xiàn)cRn與C5抑制劑已占據(jù)當(dāng)前創(chuàng)新藥的67%，而雙靶點(diǎn)藥物及無需化療的CAR-T療法有望進(jìn)一步突破難治性患者治療瓶頸。

重癥肌無力在研藥物靶點(diǎn)

重癥肌無力藥物靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

CD40
CSB-MP004936HU1

Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC₅₀ is 3.112-3.858 ng/ml.

CLEC4C
CSB-MP855470HUh7

Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C at 2μg/mL can bind Anti-CLEC4C recombinant antibody(CSB-RA855470MA1HU)，the EC₅₀ is 7.658-12.99 ng/mL.

MS4A1
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL.

TNFSF13B
CSB-MP897523HU1-B

Measured by its binding ability in a functional ELISA. Immobilized human BCMA (CSB-MP023974HU1) at 5 μg/ml can bind Biotinylated human TNFSF13B, the EC₅₀ is 0.1752-0.3657 ng/ml.

Target	Product Name	Source	Tag Info	Code
ACHE	Recombinant Bovine Acetylcholinesterase (ACHE)	E.coli	N-terminal GST-tagged	CSB-EP001154BO
Ache	Recombinant Rat Acetylcholinesterase (Ache)	E.coli	N-terminal 6xHis-tagged	CSB-EP001154RA
ACHE	Recombinant Human Motor neuron and pancreas homeobox protein 1 (ACHE)	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP001154HU
ACHE	Recombinant Human Motor neuron and pancreas homeobox protein 1（ACHE)	Mammalian cell	C-terminal hFc-tagged	CSB-MP001154HUd9
Afp	Recombinant Mouse Alpha-fetoprotein (Afp)	E.coli	N-terminal 6xHis-tagged	CSB-EP001421MO
Afp	Recombinant Mouse Alpha-fetoprotein (Afp)	E.coli	Tag-Free	CSB-EP001421MOe1
afp	Recombinant Aspergillus giganteus Antifungal protein (afp)	E.coli	N-terminal 6xHis-B2M-tagged	CSB-EP325933APN
Afp	Recombinant Mouse Alpha-fetoprotein (Afp)	Yeast	N-terminal 6xHis-tagged	CSB-YP001421MO
Afp	Recombinant Rat Alpha-fetoprotein (Afp)	E.coli	C-terminal 6xHis-tagged	CSB-EP001421RA
BTK	Recombinant Human Tyrosine-protein kinase BTK (BTK)	Baculovirus	N-terminal 10xHis-tagged	CSB-BP002867HU(A4)
BTK	Recombinant Human Tyrosine-protein kinase BTK (BTK)	Yeast	N-terminal 6xHis-tagged	CSB-YP002867HU
BTK	Recombinant Human Tyrosine-protein kinase BTK (BTK), partial	E.coli	Tag-Free	CSB-EP002867HU1
C1S	Recombinant Human Complement C1s subcomponent (C1S)	E.coli	N-terminal 10xHis-tagged	CSB-EP003657HU
C3	Recombinant Mouse Complement C3 (C3), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP365507MO
C3	Recombinant Bovine Complement C3 (C3), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP647263BO
C3	Recombinant Human Complement C3 (C3), partial	E.coli	N-terminal 6xHis-tagged	CSB-EP355590HU
C3	Recombinant Rat Complement C3 (C3), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP360475RA
C5	Recombinant Human Complement C5 (C5), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003995HU
C5	Recombinant Rat Complement C5 (C5)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP003995RA
C5	Recombinant Human Complement C5 (C5), partial	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP003995HU

● 抗體

C3 Recombinant Monoclonal Antibody
CSB-RA303909A0HU

Tested Applications:
ELISA, WB, IHC, FC

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

CD38 Recombinant Monoclonal Antibody
CSB-RA796695A0HU

Tested Applications:
ELISA, WB, IHC

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Tested Applications:
ELISA, IHC, IF, FC

- 重組抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
BTK	BTK Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA553167A0HU
C3	C3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-RA303909A0HU
C3	C3 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA699863A0HU
C5	C5 Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA003995MA1HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB	CSB-RA004888MA1HU
CD38	CD38 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA796695A0HU
CD4	CD4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA004935A0HU
CD40	CD40 Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA004936MA1HU
CLEC4C	CLEC4C Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA855470MA1HU
EGFR	Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA007479A1092phHU
EGFR	Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA007479A1068phHU
EGFR	EGFR Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-RA159341A0HU
EGFR	EGFR Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA794061A0HU
EGFR	EGFR Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC	CSB-RA159341MA1HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU

- 單克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
AFP	AFP Monoclonal Antibody	Human	ELISA, IHC	CSB-MA027711A0m
AFP	AFP Monoclonal Antibody	Human	ELISA, IHC	CSB-MA027711E0m
AFP	AFP Monoclonal Antibody	Human	ELISA, WB	CSB-MA000233
AFP	AFP Monoclonal Antibody	Human	ELISA, WB	CSB-MA099203
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
CD38	CD38 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA785760
CD4	CD4 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000228
CD4	CD4 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA043428
CD4	CD4 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA981329
CD4	CD4 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA124048
CD4	CD4 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA260243
CD4	CD4 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA570802
CD4	CD4 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA783233

- 多克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
ACHE	ACHE Antibody	Human	ELISA, IHC, IF	CSB-PA5619A0Rb
ache	ache Antibody	Zebrafish	ELISA, WB	CSB-PA863598LA01DIL
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA010202
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA010203
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA001154GA01HU
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA904467
ACHE	ACHE Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA114463
ACHE	ACHE Antibody	Human	ELISA, WB	CSB-PA547258
AFP	AFP Antibody	Human	ELISA, IHC	CSB-PA09987A0Rb
AFP	AFP Antibody	Human	ELISA, WB	CSB-PA09989A0Rb
afp	afp Antibody	Aspergillus giganteus	ELISA	CSB-PA325933LA01APN
AFP	AFP Antibody	Human	ELISA, WB	CSB-PA004875
AFP	AFP Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA001421GA01HU
AFP	AFP Antibody	Human	ELISA, WB, IHC	CSB-PA251527
AFP	AFP Antibody	Human	ELISA, WB, IHC	CSB-PA787484
AFP	AFP Antibody	Human	ELISA, IHC	CSB-PA145342
AFP	AFP Antibody	Human	ELISA, WB, IHC	CSB-PA230953
AFP	AFP Antibody	Human	ELISA, WB	CSB-PA075526
BTK	BTK Antibody	Human, Mouse	ELISA, WB, IHC, IF	CSB-PA002867LA01HU
BTK	Phospho-BTK (Y223) Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA000638

● ELISA試劑盒

Human Vascular Endothelial cell Growth Factor(VEGF) ELISA KIT
CSB-E11718h

Rat Acetylcholinesterase, AChE ELISA Kit
CSB-E11304r

Fish Acetylcholinesterase (AChE) ELISA Kit
CSB-E17001Fh

Rat Complement fragment 5,C5 ELISA Kit
CSB-E14363r

Target	Product Name	Sample Types	Detection Range	Code
ACHE	Rat Acetylcholinesterase,AChE ELISA Kit	serum, plasma, tissue homogenates	7.8 pg/mL-500 pg/mL	CSB-E11304r
AChE	Fish Acetylcholinesterase(AChE)ELISA Kit	serum, plasma, tissue homogenates	2.5 ng/mL-40 ng/mL	CSB-E17001Fh
ACHE	Human Acetylcholinesterase,AChE ELISA Kit	serum, plasma, tissue homogenates	0.94 mU/mL-60 mU/mL	CSB-E09670h
AChE	Mouse Acetylcholinesterase(AChE)ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	0.312 mU/mL-20 mU/mL	CSB-E17521m
AFP	Human Alpha-fetoprotein,AFP ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	1.563 ng/mL-100 ng/mL	CSB-E04770h
AFP	Rat Alpha-fetoprotein,AFP ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E08281r
AFP	Mouse Alpha-fetoprotein,AFP ELISA Kit	serum, plasma, tissue homogenates.	1.23 ng/ml-900 ng/ml.	CSB-E08282m
AFP	Pig Alpha-fetoprotein(AFP) ELISA kit	serum, plasma, tissue homogenates, cell culture supernates	3.12 ng/mL-200 ng/mL	CSB-EL001421PI
C1S	Human Complement C1s subcomponent(C1S) ELISA kit	serum, plasma, tissue homogenates	25 ng/mL-1600 ng/mL	CSB-EL003657HU
C3	Fish Complement 3,C3 ELISA Kit	serum, plasma	12.5 μg/mL-500 μg/mL	CSB-E09727s
C3	Human Complement 3,C3 ELISA Kit	serum, plasma, cell culture supernates, urine, saliva	4.7 ng/mL-300 ng/mL	CSB-E08665h
C3	Rat Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.625 μg/mL-40 μg/mL	CSB-E08666r
C3	Pig Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	0.625 μg/mL-10 μg/mL	CSB-E06920p
C3	Mouse Complement 3,C3 ELISA Kit	serum, plasma, tissue homogenates	93.75 ng/mL-6000 ng/mL	CSB-E08667m
C3	Rabbit Complement 3,C3 ELISA Kit	serum, plasma	27.3 ng/mL-7000 ng/mL	CSB-E08668Rb
C3	Dog Complement 3(C3)ELISA Kit	serum, plasma, tissue homogenates	0.78 μg/mL-50 μg/mL	CSB-EL003888DO
C3	Monkey Complement 3(C3)ELISA Kit	serum, plasma, cell culture supernates	4.68 ng/mL-300 ng/mL	CSB-E16528Mk
C5	Rat Complement fragment 5,C5 ELISA Kit	serum, plasma, tissue homogenates	9.38 ng/mL-600 ng/mL	CSB-E14363r
C5	Mouse Complement 5,C5 ELISA Kit	serum, plasma, tissue homogenates	0.25 ng/mL-16 ng/mL	CSB-E13802m
C5	Monkey complement C5 (C5) ELISA kit	serum, plasma, tissue homogenates	0.625 ng/mL-40 ng/mL	CSB-EL003995MK