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MERTNL Monoclonal Antibody

  • 中文名稱：
    MERTNL鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA731035A0m
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-MA731035A0m diluted at 1:50 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Overlay Peak curve showing Hela cells stained with CSB-MA731035A0m (red line) at 1:50. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 1h at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/100 dilution for 30min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    【CUSABIO貨號(hào)：CSB-MA731035A0m】MERTK單克隆抗體是針對(duì)人源MERTK受體酪氨酸激酶研發(fā)的高特異性科研試劑，適用于ELISA、免疫組化及流式細(xì)胞術(shù)等多種實(shí)驗(yàn)體系。該抗體靶向的MERTK蛋白作為TAM家族重要成員，在調(diào)控細(xì)胞凋亡抑制、巨噬細(xì)胞吞噬功能及腫瘤免疫微環(huán)境重塑中發(fā)揮關(guān)鍵作用，是腫瘤發(fā)生機(jī)制研究與免疫治療開發(fā)的重要靶點(diǎn)。產(chǎn)品采用雜交瘤技術(shù)制備，具有優(yōu)異的抗原結(jié)合特異性，經(jīng)嚴(yán)格驗(yàn)證可精準(zhǔn)識(shí)別天然構(gòu)象的MERTK蛋白，適用于體外培養(yǎng)細(xì)胞系、組織切片樣本中目標(biāo)蛋白的定性定量檢測(cè)。在腫瘤生物學(xué)研究中，該抗體可有效用于腫瘤相關(guān)巨噬細(xì)胞功能分析、免疫檢查點(diǎn)機(jī)制探索以及抗腫瘤藥物篩選等科研場(chǎng)景，為揭示MERTK在腫瘤免疫逃逸中的作用提供可靠工具。實(shí)驗(yàn)方案靈活兼容常規(guī)抗體孵育條件，滿足不同實(shí)驗(yàn)平臺(tái)需求，是癌癥基礎(chǔ)研究與轉(zhuǎn)化醫(yī)學(xué)研究的理想選擇。
  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) METRNL Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    METRNL
  • 別名：
    Meteorin like glial cell differentiation regulator antibody; Meteorin; glial cell differentiation regulator like antibody; Meteorin-like protein antibody; METRL_HUMAN antibody; Metrnl antibody
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Meteorin-like protein (46-311AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    IgG2a
  • 純化方式：
    >95%, Protein A purified
  • 克隆號(hào)：
    1F7A6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
  • 基因功能參考文獻(xiàn)：
    1. downregulation of METRNL during adipogenesis and functional induction of increased proliferation in stromal vascular fraction cells with concomitant inhibition of adipocyte differentiation may result in hypertrophic AT accumulation PMID: 27748745
    2. Overexpression of METRNL inhibited mineralized nodule formation. PMID: 27716826
    3. Data suggest that there is no correlation between serum Metrnl levels and BMI (body mass index) in humans. PMID: 26307585
    4. Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin PMID: 24393292
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Meteorin family
  • 組織特異性：
    Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 27584

    OMIM: 616241

    KEGG: hsa:284207

    STRING: 9606.ENSP00000315731

    UniGene: Hs.378821