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NT5E

NT5E,即5'-核苷酸外酶,別名CD73、eN、eNT、CALJA。NT5E蛋白是一種細(xì)胞表面酶,主要功能是催化細(xì)胞外的核苷酸轉(zhuǎn)化為可透過膜的核苷,這一過程對(duì)于調(diào)節(jié)細(xì)胞外的ATP水平和腺苷信號(hào)至關(guān)重要。NT5E通過將ATP轉(zhuǎn)化為腺苷,進(jìn)而影響免疫細(xì)胞的功能和炎癥反應(yīng)。
在生物學(xué)意義上,NT5E在多種生理和病理過程中發(fā)揮作用,包括淋巴細(xì)胞分化、免疫調(diào)節(jié)以及腫瘤微環(huán)境中的免疫逃逸。NT5E的異常表達(dá)與多種疾病相關(guān),如關(guān)節(jié)和動(dòng)脈的鈣化、炎癥性腸病以及某些癌癥。

熱銷產(chǎn)品

Recombinant Human 5'-nucleotidase (NT5E) (Active) (CSB-MP723415HU)

驗(yàn)證數(shù)據(jù)

CSB-MP723415HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP723415HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD73 at 2 μg/ml can bind Anti- CD73 Rabbit Monoclonal Antibody(CSB-RA978310A0HU), the EC50 is 3.212-4.525 ng/ml.

NT5E Recombinant Monoclonal Antibody (CSB-RA723415MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA723415MA1HU

Overlay Peak curve showing PC3 cells surface stained with CSB-RA723415MA1HU (red line) at 1:100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was mouse IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

NT5E Antibodies

NT5E for Homo sapiens (Human)

NT5E Proteins

NT5E Proteins for Mus musculus (Mouse)

NT5E Proteins for Homo sapiens (Human)

NT5E ELISA Kit

NT5E ELISA Kit for Mus musculus (Mouse)

NT5E ELISA Kit for Homo sapiens (Human)

NT5E ELISA Kit for Rattus norvegicus (Rat)