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CTLA4

CTLA4,即細(xì)胞毒性T淋巴細(xì)胞相關(guān)蛋白4,別名CD152。CTLA4是一種主要由活化的T細(xì)胞表達(dá)的跨膜蛋白,由CTLA4基因編碼。它的作用機(jī)制是通過與B7家族分子(如CD80和CD86)結(jié)合,抑制T細(xì)胞的激活和增殖,從而調(diào)節(jié)免疫反應(yīng)。CTLA4的活性在自身免疫性疾病和抗腫瘤免疫中具有重要作用,其表達(dá)水平的變化可能影響免疫耐受和免疫病理過程。CTLA4的功能異常與某些自身免疫性疾病如系統(tǒng)性紅斑狼瘡、類風(fēng)濕關(guān)節(jié)炎等有關(guān),同時(shí),CTLA4也是免疫檢查點(diǎn)抑制劑治療的靶點(diǎn)之一,相關(guān)藥物如伊普利姆瑪(Ipilimumab)已用于治療黑色素瘤等癌癥。

熱銷產(chǎn)品

Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) (CSB-MP006163HU1)

驗(yàn)證數(shù)據(jù)

CSB-MP006163HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP006163HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody(CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP006163HU1

The purity of CTLA4 was greater than 90% as determined by SEC-HPLC.

CTLA4 Recombinant Monoclonal Antibody (CSB-RA213310A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA213310A0HU

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA213310A0HU

IHC image of CSB-RA213310A0HU diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CTLA4 Antibodies

CTLA4 for Homo sapiens (Human)

CTLA4 Proteins

CTLA4 Proteins for Homo sapiens (Human)

CTLA4 Proteins for Oryctolagus cuniculus (Rabbit)

CTLA4 Proteins for Mus musculus (Mouse)

CTLA4 Proteins for Sus scrofa (Pig)

CTLA4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CTLA4 ELISA Kit

CTLA4 ELISA Kit for Homo sapiens (Human)

CTLA4 ELISA Kit for Mus musculus (Mouse)