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  4. MMAE&MMAF Monoclonal Antibody

MMAE&MMAF Monoclonal Antibody

  • 中文名稱：
    MMAE&MMAF鼠單克隆抗體
  • 貨號：
    CSB-MA903890I1m
  • 規(guī)格：
    ￥3000
  • 圖片：
    • MMAE&MMAF antibody on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%.
    • The Binding Activity of Disitamab vedotin (Synonyms: RC48) with Anti-MMAE&MMAF antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) at 2 μg/mL can bind Anti-MMAE antibody, the EC50 is 1.908 to 2.492 ng/mL.
    • The Binding Activity of Depatuxizumab mafodotin (Synonyms: ABT-414) with Anti-MMAE&MMAF antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Depatuxizumab mafodotin (Synonyms: ABT-414) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 1.927 to 3.280 ng/mL.
    • The Binding Activity of Disitamab vedotin (Synonyms: RC48) and Depatuxizumab mafodotin (Synonyms: ABT-414) with Anti-MMAE&MMAF antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) and Depatuxizumab mafodotin (Synonyms: ABT-414) at 2 μg/mL can bind Anti-MMAE&MMAF antibody, the EC50 is 1.908 to 2.492 ng/mL and 1.927 to 3.280 ng/mL, respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CUSABIO貨號：CSB-MA903890I1m MMAE&MMAF單克隆抗體是針對抗體偶聯(lián)藥物（ADC）中常用細胞毒素成分MMAE（單甲基澳瑞他汀E）和MMAF（單甲基澳瑞他汀F）開發(fā)的高特異性科研試劑。該產(chǎn)品采用雜交瘤技術(shù)制備，能夠精準識別MMAE和MMAF分子結(jié)構(gòu)中的特征表位，在ELISA檢測中展現(xiàn)優(yōu)異的選擇性和靈敏度，適用于ADC藥物開發(fā)過程中有效載荷的定量分析、藥物代謝動力學(xué)研究及質(zhì)量控制等科研場景。作為經(jīng)過嚴格驗證的單克隆抗體，其批間穩(wěn)定性強、交叉反應(yīng)性低，可實現(xiàn)對復(fù)雜生物樣本中MMAE/MMAF分子的準確定量。研究人員可借助該產(chǎn)品建立高重復(fù)性的ELISA檢測體系，用于評估ADC藥物的載藥效率、體內(nèi)外釋放動力學(xué)及生物分布研究，為優(yōu)化ADC藥物設(shè)計提供可靠數(shù)據(jù)支持。本產(chǎn)品特別適用于從事腫瘤靶向治療、ADC創(chuàng)新藥開發(fā)及相關(guān)機制研究的科研團隊，是探索新型抗癌療法的重要工具試劑。
  • 基因名：
    MMAE; MMAF
  • 別名：
    MMAE, Monomethyl auristatin E, SGD-1010, Vedotin; MMAF, Monomethylauristatin F
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Homo sapiens (Human)
  • 免疫原：
    MMAE-BSA
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    IgG2b
  • 純化方式：
    >95%, Protein G purified
  • 克隆號：
    25G12B5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價