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  4. Recombinant Human Beta-defensin 104 protein (DEFB104A)

Recombinant Human Beta-defensin 104 protein (DEFB104A)

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  • 中文名稱：
    Recombinant Human Beta-defensin 104 protein(DEFB104A) (Active)
  • 貨號：
    CSB-AP003061HU
  • 規(guī)格：
    ￥852
  • 圖片：
  • 其他：

產品詳情

  • 純度：
    >98% as determined by SDS-PAGE.
  • 內毒素：
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性：
    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0 ng/ml.
  • 基因名：
    DEFB104A
  • Uniprot No.：
  • 別名：
    BD 4; BD-4; BD4; beta 104; beta 4 Defensin; Beta defensin 4; Beta-defensin 104; Beta-defensin 4; D104A_HUMAN; DEFB-4; DEFB104B; Defensin; Defensin beta 104; Defensin beta 4 precursor; hBD 4; hBD-4; hBD4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.Coli
  • 分子量：
    6.0 kDa
  • 表達區(qū)域：
    23-72aa
  • 氨基酸序列
    EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
  • 蛋白標簽：
    Tag-Free
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    0.2 μm filtered 20 mM PB, pH 7.4, 130 mM NaCl ,lyophilized
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    5-10 business days
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
  • 基因功能參考文獻：
    1. Beta-defensin 104 displays antimicrobial activity against S. carnosus, E. coli, S. cerevisiae, and P. aeruginosa (strong). PMID: 11481241
    2. TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4 PMID: 23198942
    3. Data suggest an activation of b-defensin-4 induction, in human knee meniscus by the osteoarthritis inflammatory process as a result of an endogenous antibiotic defense mechanism accompanied by an intrinsic effort of tissue remodeling. PMID: 21879330
    4. Our results suggest that copy number variation of DEFB4 may not contribute to the pathogenesis of Behcet's disease. PMID: 21385545
    5. Analysis of the DEFB4 promoter region shows remarkably high density of sequence variabilities. PMID: 20445567
    6. The variations in the genes encoding human beta-defensin-1 and -2 may be associated with the risk of severe acute pancreatitis. PMID: 20720450
    7. Data show that beta-defensin cluster (DEFB4, DEFB103 and DEFB104) varied between 2 and 9 copies per genome, and high copy numbers (>4) were underrepresented among patients, suggesting that increased copy numbers could protect from CD. PMID: 20483368
    8. We report here the application of small ubiquitin-related modifier (SUMO) fusion technology to the expression and purification of cationic antibacterial peptide hBD4. PMID: 20526896
    9. This study demonstrates, the involvement of NOD1 and DEFB4 in direct killing of Helicobacter pylori bacteria by epithelial cells and confirms the importance of NOD1 in host defence mechanisms against cagPAI(+)Helicobacter pylori infection. PMID: 20039881
    10. The mRNA level of the beta defensin 4 did not differ significantly between the two subgroups. PMID: 20128731
    11. elevated DEFB4 copy number is a risk factor for Crohn's disease PMID: 19809410
    12. There is an association of four common DEFB104 haplotypes with the risk of prostate cancer in two independent patient cohorts. PMID: 18515986

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Beta-defensin family
  • 組織特異性：
    High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested.
  • 數據庫鏈接：

    HGNC: 18115

    KEGG: hsa:107984148

    STRING: 9606.ENSP00000322191

    UniGene: Hs.559507