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  4. Recombinant Human Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1), partial (Active)

Recombinant Human Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1), partial (Active)

In Stock
  • 貨號：
    CSB-MP011624HU1
  • 規(guī)格：
    ￥828
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized Human PTPRD protein (CSB-MP019051HU(A4)) at 2 μg/ml can bind Human IL1RAPL1 protein. The EC50 is 2.645-3.098 ng/mL. Biological Activity Assay
    • The purity of IL1RAPL1 was greater than 95% as determined by SEC-HPLC
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC.
  • 內(nèi)毒素：
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性：
    Measured by its binding ability in a functional ELISA. Immobilized Human PTPRD protein (CSB-MP019051HU(A4)) at 2 μg/mL can bind Human IL1RAPL1 protein. The EC50 is 2.645-3.098 ng/mL.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Interleukin-1 receptor accessory protein-like 1; EC:3.2.2.6; IL-1-RAPL-1;?IL-1RAPL-1; ?IL1RAPL-1;Oligophrenin-4; Three immunoglobulin domain-containing IL-1 receptor-related 2?(TIGIRR-2); X-linked interleukin-1 receptor accessory protein-like 1; IL1RAPL1; OPHN4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    66.4 kDa
  • 表達(dá)區(qū)域：
    19-357aa
  • 氨基酸序列
    LKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYT
  • 蛋白標(biāo)簽：
    C-terminal hFc1-tagged
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.
  • 基因功能參考文獻(xiàn)：
    1. Our study revealed that the expression of IL-1R8 significantly increased on in vitro-activated CD4+ T cells and was markedly higher on CD4+ T cells from allergic rhinitis patients than on cells from healthy controls. PMID: 29730558
    2. IL-1R8 serves as a checkpoint for NK cell maturation and effector function; its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection in mice PMID: 29072292
    3. Altered DNA methylation in IL1RAPL1 involves in the etiology of Bipolar disorder and Major Depressive disorder . PMID: 27440233
    4. rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL-13 production in Latin American children. PMID: 28120837
    5. Our study expands the molecular repertoire of IL1RAPL1 mutations in intellectual disability and points out the need of more accurate clinical descriptions to better define the related phenotype PMID: 27470653
    6. It was indicated that a defect in IL1RAPL1 that controls excitatory synapsis formation results in the excitation-inhibition balance affecting various cerebral functions. PMID: 25864829
    7. Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis. PMID: 25305082
    8. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
    9. The IL1RAPL1 gene is of interest as a candidate gene for autism spectrum disorder as mutations or deletions in the gene have previously been reported in individuals from families with ASD. PMID: 21491612
    10. Intragenic deletions in IL1RAPL1are relevant to the pathogenesis of X-linked mental retardation. PMID: 21271657
    11. crystal structure at 2.3-A resolution of the TIR domain of IL-1RAPL PMID: 15123616
    12. Nearly all patients with deletions involving DAX1, but not DMD, had mental retardation if IL1RAPL1 was deleted. If ILIRAPLI & DMD were intact, the patients with DAX1 deletions only rarely had normal development. PMID: 15300857
    13. Report confirms the role of the IL1RAPL1 gene in causing nonspecific mental retardation in males. PMID: 16470793
    14. DMD gene and its immediately distal neighbor, the 1.8 Mb IL1RAPL1 gene are abundantly expressed in normal brain but were dramatically underexpressed in every brain tumor cell line and xenograft. PMID: 18253029
    15. Combined data suggested that IL1RAPL1 affected human cognitive ability to some extent, especially the memory and concentration capability. PMID: 18467032
    16. The function of truncated IL1RAPL1 protein in an autistic female with Asperger syndrome is severely altered in hippocampal neurons, demonstrated by its effect on neurite outgrowth activity. PMID: 18801879
    17. IL1RAPL1 plays an important role in the etiology of X-linked mental retardation. PMID: 19012350

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  • 相關(guān)疾病：
    Mental retardation, X-linked 21 (MRX21)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon. Cell projection, dendrite.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal live
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5996

    OMIM: 300143

    KEGG: hsa:11141

    STRING: 9606.ENSP00000305200

    UniGene: Hs.658912