BCL7A Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q4VC05
基因名：

BCL7A
別名：

B cell CLL/lymphoma 7 antibody; B cell CLL/lymphoma 7 protein family member A antibody; B cell CLL/lymphoma 7A antibody; B-cell CLL/lymphoma 7 protein family member A antibody; BCL 7 antibody; BCL7 antibody; bcl7a antibody; BCL7A_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human Bcl-7a.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

基因功能參考文獻(xiàn)：
1. BCL7A, BRWD3, and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 and IRF4 with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations. PMID: 29166413
2. Data suggest that BCL7A may play an important role in cutaneous T-cell lymphoma (CTCL) carcinogenesis. PMID: 22856870
3. Report describes BCL7A protein expression in normal lymphoid tissues and lymphomas using immunohistochemistry. PMID: 23043359
4. Promoter hypermethylation of BCL7a is associated with cutaneous T-cell lymphoma PMID: 15897551
5. deletion of genes BCL7A in early-stage mycosis fungoides. PMID: 18663754
6. Variants in BCL7A were strongly related to diffuse large B-cell lymphoma. PMID: 19336552
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相關(guān)疾?。?/div>
Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.
蛋白家族：

BCL7 family
數(shù)據(jù)庫鏈接：

HGNC: 1004

OMIM: 601406

KEGG: hsa:605

UniGene: Hs.530970