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  4. COL4A6 Antibody

COL4A6 Antibody

  • 中文名稱：
    COL4A6兔多克隆抗體
  • 貨號：
    CSB-PA001750
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using COL4A6 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    COL4A6Collagen alpha-6(IV) chain antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human COL4A6.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
  • 基因功能參考文獻：
    1. Mutation in COL4A6 gene is associated with gastric cancer peritoneal carcinomatosis. PMID: 26811494
    2. COL4A6 is associated with X-linked nonsyndromic hearing loss. PMID: 23714752
    3. We showed that TPM2, CLU, and COL4A6 mRNA levels are downregulated in prostate cancer. PMID: 23621580
    4. expression of collagen type IV alpha6 chain in the smooth muscle BM of the gastrointestinal tract is restricted to the esophagus in humans PMID: 20951201
    5. The expression of collagen type IV was significantly decreased in colorectal cancer tissues. PMID: 18782525
    6. Enhanced expression of collagen type IV is associated with liver metastases from gastrointestinal tumours PMID: 15679046
    7. This study showed that in some cases of esophageal squamous cell carcinoma the alpha5/alpha6 (IV) chains are expressed linearly around the cancer cell nests and the alpha5/alpha6 (IV) chain expression is one prognostic factor of ESCC. PMID: 17955302
    8. Type IV collagen alpha6 chain-derived noncollagenous domain 1 (alpha6NC1) is an endogenous inhibitor of angiogenesis and tumor growth. PMID: 18074349
    9. Meningiomas increase in size through increased production of extracellular matrix; furthermore, the proliferation of cells typically associated with neoplasia requires considerable interaction with the extracellular matrix. PMID: 18474427

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  • 相關疾病：
    Deafness, X-linked, 6 (DFNX6)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 蛋白家族：
    Type IV collagen family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2208

    OMIM: 300914

    KEGG: hsa:1288

    STRING: 9606.ENSP00000361290

    UniGene: Hs.145586