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DSC1 Antibody

  • 中文名稱：
    DSC1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007189ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA007189ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA007189ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DSC1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DSC1
  • 別名：
    DSC1 antibody; CDHF1 antibody; Desmocollin-1 antibody; Cadherin family member 1 antibody; Desmosomal glycoprotein 2/3 antibody; DG2/DG3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Desmocollin-1 protein (480-690AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.
  • 基因功能參考文獻(xiàn)：
    1. DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC. PMID: 27601166
    3. Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases. PMID: 23975055
    4. High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas. PMID: 22438068
    5. The ultrastructural modifications of desmosomes during terminal differentiation of hair follicles are paralleled by the modulation of the synthesis of desmocollin 1. PMID: 15140019
    6. in majority of patients with Netherton syndrome, Dsg1 & Dsc1 were reduced in living layers of epidermis; SCTE-like & SCCE-like activities were increased, suggesting these proteases participate in premature degradation of corneodesmosomal cadherins PMID: 16628198
    7. Increased Dsc1 protein is associated with colorectal cancer PMID: 17088906

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
  • 組織特異性：
    Strongly expressed in epidermis, less in lymph node and tongue.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3035

    OMIM: 125643

    KEGG: hsa:1823

    STRING: 9606.ENSP00000257198

    UniGene: Hs.567260