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EGR3 Antibody

  • 中文名稱：
    EGR3兔多克隆抗體
  • 貨號：
    CSB-PA007486LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, A549 whole cell lysate
      All lanes: EGR3 antibody at 3.5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 43, 39 kDa
      Observed band size: 43 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) EGR3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EGR3
  • 別名：
    EGR3 antibody; PILOTEarly growth response protein 3 antibody; EGR-3 antibody; Zinc finger protein pilot antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Early growth response protein 3 protein (201-281AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，EGR3 Antibody (CSB-PA007486LA01HU)，的標(biāo)記方式是Non-conjugated。對于EGR3 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA007486LB01HU EGR3 Antibody, HRP conjugated ELISA
    FITC CSB-PA007486LC01HU EGR3 Antibody, FITC conjugated
    Biotin CSB-PA007486LD01HU EGR3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probable transcription factor involved in muscle spindle development.
  • 基因功能參考文獻：
    1. KSRP decreased EGR3 mRNA stability in an ARE-independent manner. PMID: 28847731
    2. miR-718 acts as a tumor suppressive microRNA in hepatocellular carcinoma via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC PMID: 28070994
    3. EGR3 contributes to cell growth inhibition via upregulation of FasL in Hepatocellular carcinoma. PMID: 28098878
    4. These findings support previously reported associations between EGR3 and schizophrenia. PMID: 26474411
    5. EGR3 promotes excessive production of IL6 and IL8 observed during the progression of prostate cancer. PMID: 25633035
    6. Data shows association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China PMID: 24886494
    7. Genetic variation in EGR3 may affect prefrontal function through neurodevelopment PMID: 23962955
    8. These results provide the first evidence that Egr-3, is up-regulated in scleroderma and is necessary and sufficient for profibrotic responses. PMID: 23906810
    9. Decreased EGR3 expression might play a critical role in the differentiation, proliferation, metastasis and progression of gastric cancer cells. PMID: 23460371
    10. These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter. PMID: 23935197
    11. Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity PMID: 23904169
    12. Egr3 mRNA expression reveals that Egr3 mRNA expression is increased in tumor cells of non-relapsed samples compared to normal prostate cells, but is significantly lower in relapsed samples compared to non-relapse. PMID: 23342084
    13. EGR3, a gene that translates environmental stimuli into long-term changes in the brain, may be associated with risk for child bipolar disorder 1. PMID: 22370066
    14. Study supports the association of EGR3 with schizophrenia in Han Chinese sample. PMID: 22276163
    15. EGR3 gene may play an important role in schizophrenia susceptibility PMID: 22425949
    16. EGR3 bound to the TREM-1 promoter. PMID: 21421043
    17. This study demoistrated that ERG3 are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
    18. SNP rs35201266 in intron 1 of the EGR3 gene showed a significant association with schizophrenia PMID: 20687139
    19. Egr-3 is a critical determinant of VEGF signaling in activated endothelial cells PMID: 19965691
    20. Vascularendothelial growth factor induces expression of NR4A nuclear receptors and Egr3 via KDR and KDR-mediated signaling mechanisms. PMID: 14525795
    21. data suggest that Egr3 is a target for the estrogen receptor alpha PMID: 15171706
    22. These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene. PMID: 17360599
    23. findings indicate that Egr3 has an essential downstream role in VEGF-mediated endothelial functions leading to angiogenesis and may have particular relevance for adult angiogenic processes involved in vascular repair and neovascular disease PMID: 18059339
    24. Enforced expression of Egr3 transgene, from the CD2 antigen promoter, facilitates development of RAG2-deficient double-negative (DN) stage 3 thymocytes to the DN4 stage and subsequently to the double-positive stage of development. PMID: 19124717

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    EGR C2H2-type zinc-finger protein family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3240

    OMIM: 602419

    KEGG: hsa:1960

    STRING: 9606.ENSP00000318057

    UniGene: Hs.534313