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FDXR Antibody

  • 中文名稱(chēng)：
    FDXR兔多克隆抗體
  • 貨號(hào)：
    CSB-PA008575GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Adrenodoxin reductase antibody; ADRO_HUMAN antibody; ADXR antibody; AR antibody; FDXR antibody; Ferredoxin NADP(+) reductase antibody; Ferredoxin reductase antibody; Ferredoxin--NADP(+) reductase antibody; mitochondrial antibody; NADPH adrenodoxin oxidoreductase mitochondrial antibody; NADPH:adrenodoxin oxidoreductase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FDXR
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
  • 基因功能參考文獻(xiàn)：
    1. These data provide further insight into the pathogenic mechanism of FDXR-mediated central neuropathy, and suggest an avenue for mechanistic studies that will ultimately inform treatment. PMID: 30250212
    2. we identified a novel disease-causing gene FDXR associated with mitochondrial diseases. The biallelic FDXR mutations cause optic atrophy and neuropathy. we found that FDXR levels are significantly lower in the patient fibroblast cells with the homozygous mutations R392W. Fourteen missense or nonsense FDXR mutations were identified in this study and eight of them (I143F, V158M, T211A, I213F, K280*, R315*, C359Y, D374N) clu PMID: 29040572
    3. Using surface plasmon resonance, physiologically relevant concentrations of isatin (25-100 muM) were found to increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH-dependent adrenodoxin reductase (ADR). PMID: 28905435
    4. Mutation in FDXR gene is associated with Sensorial Neuropathies. PMID: 28965846
    5. NOS-3 overexpression resulted in an increased sensitivity to anti-Fas induced cell death, independently of AR expression and CatD activity. PMID: 25712867
    6. These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 binding to the intronic enhancer of the FDXR gene PMID: 24321386
    7. results suggest that both FDX1 and FDX2 and their likely reductase partner, FDXR, contribute to iron-sulfur cluster biogenesis PMID: 22101253
    8. comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase [cytochrome P450scc] PMID: 12137805
    9. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis PMID: 12370809
    10. ADXR rate of hydroxylation was linear with incubation time. PMID: 12782149

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  • 亞細(xì)胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein.
  • 蛋白家族：
    Ferredoxin--NADP reductase type 1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3642

    OMIM: 103270

    KEGG: hsa:2232

    STRING: 9606.ENSP00000462972

    UniGene: Hs.69745