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  4. FEZF1 Antibody, Biotin conjugated

FEZF1 Antibody, Biotin conjugated

  • 中文名稱：
    FEZF1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA008602LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FEZF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FEZF1
  • 別名：
    FEZ antibody; FEZ family zinc finger 1 antibody; Fez family zinc finger protein 1 antibody; fez like antibody; fezf1 antibody; FEZF1_HUMAN antibody; Zinc finger protein 312 like antibody; Zinc finger protein 312B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Fez family zinc finger protein 1 protein (1-115AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors.
  • 基因功能參考文獻：
    1. FEZF1 was significantly increased in glioma tissues. Over-expressed FIZF1 was associated with reduced survival. PMID: 30030762
    2. loss of FEZF1 impairs the pluripotency exit of hESCs during neural specification, which partially explains the neural induction defect caused by FEZF1 deletion. PMID: 29318501
    3. FEZF1plays a novel role in regulating the malignant behavior of glioma stem cells as a part of Linc00152/miR-103a-3p/FEZF1/CDC25A axis.FEZF1 up-regulated the promoter activities and bound to the promoters of CDC25A in glioma stem cells. PMID: 28651608
    4. High expression of long noncoding RNA FEZF1 was significantly associated with later stage and higher grade of gastric cancer. PMID: 29239821
    5. SEZ6L, HISPPD1, FEZF1, SAMD11 gene variants may be associated with autism spectrum disorder. PMID: 26204995
    6. Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types. [Review] PMID: 24913420
    7. Mutations in FEZF1 cause Kallmann syndrome. PMID: 25192046
    8. the aberrant expression of ZNF312b promotes gastric tumorigenesis through epigenetic modification of its promoter region and provides a molecular mechanism for ZNF312b expression to contribute to the progression of gastric cancer. PMID: 21170990
    9. Study is the first to report that ZNF312b, a novel transcription factor, was associated with tumorigenicity of gastric cancer. PMID: 19318583
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19401682

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  • 相關(guān)疾?。?/div>
    Hypogonadotropic hypogonadism 22 with or without anosmia (HH22)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 22788

    OMIM: 613301

    KEGG: hsa:389549

    STRING: 9606.ENSP00000411145

    UniGene: Hs.553970