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  4. GRAMD4 Antibody, Biotin conjugated

GRAMD4 Antibody, Biotin conjugated

  • 中文名稱：
    GRAMD4兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA764225LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) GRAMD4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GRAMD4
  • 別名：
    GRAMD4; DIP; KIAA0767; GRAM domain-containing protein 4; Death-inducing protein
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GRAM domain-containing protein 4 protein (23-161AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response.
  • 基因功能參考文獻：
    1. The expression of GRAMD4 is up-regulated in hepatocellular carcinoma cell(HCC cell) lines and HCC tissues, and the increased expression is correlated with the clinicopathological characteristics of HCC. PMID: 23388340
    2. GRAMD4 induces changes in Bcl-2 and Bax protein levels PMID: 21127500
    3. localizes to the mitochondria, upregulated following E2F1 induction PMID: 15565177
    4. DIP induces p53-independent caspase-dependent and -independent apoptosis. DIP is localized in the mitochondria. DIP accumulates upon E2F1 activation. PMID: 15565177
  • 亞細胞定位：
    Mitochondrion membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in lung and in primary lung squamous cell carcinoma (LSCC).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29113

    OMIM: 613691

    KEGG: hsa:23151

    STRING: 9606.ENSP00000354313

    UniGene: Hs.475150