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  4. INTS3 Antibody

INTS3 Antibody

  • 中文名稱：
    INTS3兔多克隆抗體
  • 貨號：
    CSB-PA011761GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    INTS3
  • 別名：
    INTS3 antibody; C1orf193 antibody; C1orf60 antibody; Integrator complex subunit 3 antibody; Int3 antibody; SOSS complex subunit A antibody; Sensor of single-strand DNA complex subunit A antibody; SOSS-A antibody; Sensor of ssDNA subunit A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human INTS3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
  • 基因功能參考文獻(xiàn)：
    1. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites. PMID: 23986477
    2. INTS3 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability. PMID: 19683501
    3. INT3 plays a key role in the DNA damage response PMID: 19759019
    4. INTS3 controls the hSSB1-mediated DNA damage response. PMID: 19786574
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Note=Localizes to nuclear foci following DNA damage.
  • 蛋白家族：
    Integrator subunit 3 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26153

    OMIM: 611347

    KEGG: hsa:65123

    STRING: 9606.ENSP00000318641

    UniGene: Hs.438723