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KIAA0226L Antibody

  • 中文名稱：
    KIAA0226L兔多克隆抗體
  • 貨號(hào)：
    CSB-PA003112GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RUBCNL
  • 別名：
    C13orf18 antibody; CM018_HUMAN antibody; FLJ21562 antibody; FLJ43762 antibody; KIAA0226 like antibody; KIAA0226L antibody; RP11-247M1.4 antibody; Uncharacterized protein C13orf18 antibody; Uncharacterized protein KIAA0226-like antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human C13orf18
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis. May act as a tumor suppressor.
  • 基因功能參考文獻(xiàn)：
    1. Pacer localizes to autophagic structures and positively regulates autophagosome maturation. PMID: 28306502
    2. Re-activation of C13ORF18 led to partial demethylation of the C13ORF18 promoter and decreased repressive histone methylation. PMID: 23522960
    3. Data suggest that the four-gene methylation panel might provide an alternative triage test after primary high-risk papillomavirus (hr-HPV) testing. PMID: 21796628
    4. Methylation of C13orf18 in cervical scrapings is strongly associated with high-grade cervical intraepithelial neoplasia and cervical cancer. PMID: 19843677
  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein.
  • 組織特異性：
    Expressed weakly in cervical carcinoma cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20420

    KEGG: hsa:80183

    STRING: 9606.ENSP00000374558

    UniGene: Hs.98117