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  4. KYNU Antibody

KYNU Antibody

  • 中文名稱：
    KYNU兔多克隆抗體
  • 貨號：
    CSB-PA621970ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: KYNU antibody at 3.26μg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Lane 3: THP-1 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 53, 35 kDa
      Observed band size: 53 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA621970ESR1HU at dilution of 1:100
    • Immunoprecipitating KYNU in Hela whole cell lysate
      Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA621970ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
      Lane 2: CSB-PA621970ESR1HU (4μg) + Hela whole cell lysate (500μg)
      Lane 3: Hela whole cell lysate (20μg)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KYNU Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KYNU
  • 別名：
    kynU antibody; KYNU_HUMAN antibody; kynureninase (L-kynurenine hydrolase) antibody; Kynureninase antibody; L-kynurenine hydrolase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Kynureninase protein (1-307AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IP
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
  • 基因功能參考文獻：
    1. Our results suggest that tryptophan metabolism might dichotomously modulate immune responses, with KYNU as a switch between immunosuppressive versus inflammatory outcomes. PMID: 26725996
    2. A rare variant at the KYNU gene is associated with essential hypertension in the Han Chinese population. PMID: 22012986
    3. The Lys412Glu polymorphism of the KYNU gene in a hypertensive candidate chromosomal region is associated with essential hypertension in Han Chinese. PMID: 16080802
  • 相關疾?。?/div>
    Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)
  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Kynureninase family
  • 組織特異性：
    Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6469

    OMIM: 236800

    KEGG: hsa:8942

    STRING: 9606.ENSP00000264170

    UniGene: Hs.470126