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LBH Antibody, FITC conjugated

  • 中文名稱：
    LBH兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA700659LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LBH Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LBH
  • 別名：
    hLBH antibody; lbh antibody; LBH_HUMAN antibody; Limb bud and heart development antibody; Limb bud and heart development homolog (mouse) antibody; Protein LBH antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein LBH protein (1-105AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
  • 基因功能參考文獻(xiàn)：
    1. LBH was significantly down-regulated in lung cancer tissue samples and was correlated with the prognosis and clinical characteristics of lung cancer patients. Survival analysis revealed that LBH-negative expression was associated with poor overall survival of LUAD patients (P = 0.021). PMID: 29788015
    2. Low LBH level, caused by a rheumatoid arthritis risk allele, is a risk factor for aggressive fibroblast-like synoviocyte behavior. PMID: 27159840
    3. The expression levels of LBH mRNA in patients with SLE were significantly decreased compared with those in normal controls (P < 0.001). No significant differences were found between LBH mRNA expression levels and SLE disease activity scores, SNP rs7579944 and rs906868. PMID: 26134586
    4. LBH normally induces NPC cell cycle arrest at the G1/S transition, and LBH can suppress the growth of transplanted NPC tumors in vivo by downregulating LMP1-mediated NF-kappaB transcriptional activity. PMID: 25557837
    5. LBH is a candidate gene for synovial pathology in rheumatoid arthritis. It is regulated by growth factors and modulates cell growth in primary fibroblast-like synoviocytes. PMID: 25707478
    6. results showed that the interaction of LBH and alphaB-crystallin may inhibit synergistically the transcriptional regulation of p53 and p21 PMID: 20587334
    7. LBH is aberrantly overexpressed in mammary tumors of mouse mammary tumor virus (MMTV)-Wnt1-transgenic mice and in aggressive basal subtype human breast cancers that display Wnt/beta-catenin hyperactivation. PMID: 20606007
    8. LBH is implicated as a candidate gene for congenital heart disease associated with partial trisomy 2p syndrome PMID: 15958514
    9. These results suggest that hLBH proteins may act as a transcriptional activator in mitogen-activated protein kinase signaling pathway to mediate cellular functions. PMID: 17390236

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  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    LBH family
  • 組織特異性：
    Highly expressed in heart, and expressed at low levels in placenta, lung, skeletal muscle, kidney and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 29532

    OMIM: 611763

    KEGG: hsa:81606

    STRING: 9606.ENSP00000378733

    UniGene: Hs.567598