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  4. Loxl1 Antibody, FITC conjugated

Loxl1 Antibody, FITC conjugated

  • 中文名稱：
    Loxl1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA013040LC01MO
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Mus musculus (Mouse) Loxl1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    Loxl1
  • 別名：
    Loxl1 antibody; Lox2 antibody; Loxl antibody; Lysyl oxidase homolog 1 antibody; EC 1.4.3.- antibody; Lysyl oxidase 2 antibody; Lysyl oxidase-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Mouse
  • 免疫原：
    Recombinant Mouse Lysyl oxidase homolog 1 protein (95-607AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Active on elastin and collagen substrates.
  • 基因功能參考文獻：
    1. findings strongly suggested that elastin crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin. PMID: 29366776
    2. LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females PMID: 26538021
    3. Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma. PMID: 24425853
    4. There is a possible fundamental role of LOXL-1 in cardiac hypertrophy. PMID: 22763477
    5. loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype PMID: 15482472
    6. Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted long-term potentiation compared to LOXL +/+ mice. PMID: 16157454
    7. LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders PMID: 16436666
    8. LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues PMID: 18265927
    9. LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin disorganization may lead to such functional abnormalities. PMID: 18495804
    10. Loxl1(-/-) males bred with control females demonstrated relative fecundity values intermediate between Loxl1(-/-) pairs (lowest fecundity) and control pairs (highest fecundity), suggesting a component of male-factor infertility. PMID: 19201700

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  • 亞細胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Lysyl oxidase family
  • 數(shù)據(jù)庫鏈接：