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  4. NEU2 Antibody

NEU2 Antibody

  • 中文名稱：
    NEU2兔多克隆抗體
  • 貨號：
    CSB-PA896716ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA896716ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NEU2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NEU2
  • 別名：
    Cytosolic sialidase antibody; MGC129579 antibody; N acetyl alpha neuraminidase 2 antibody; N-acetyl-alpha-neuraminidase 2 antibody; Neu2 antibody; NEUR2_HUMAN antibody; Neuraminidase 2 antibody; OTTHUMP00000164374 antibody; SIAL2 antibody; Sialidase 2 antibody; Sialidase-2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sialidase-2 protein (171-380AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues.
  • 基因功能參考文獻(xiàn)：
    1. Synchrotron radiation reflectometry was used to access the transverse structure of model membranes under the action of the human sialidase NEU2, down to the Angstrom length scale PMID: 28087363
    2. cytosolic GBA3 is likely involved in the catabolism of cytosolic sialyl free N-glycans, possibly by stabilizing the activity of the NEU2 protein PMID: 26193330
    3. Circular dichroism (CD) spectra at variable temperatures have been recorded for human cytosolic sialidase NEU2 in buffered water solutions and in the presence of divalent cations. PMID: 25033330
    4. Q136K is a novel mutation in an expressed NEU2 protein that was discovered during crystallographic analysis. PMID: 23908028
    5. the present study demonstrated NEU2 expression to be detectable but very low in many human tissues and cells, and suggested possible functional roles in PC-3 prostate cancer cells. PMID: 23068092
    6. NEU2 appears to be activated when lysine 45 and glutamine 112 are mutated to alanine. PMID: 22228546
    7. HsNEU2 differentially recognizes the type of sialosyl linkage, the aglycone part of the substrate, and the supramolecular organization (monomer/micelle/vesicle) of gangliosides PMID: 14613940
    8. the first high resolution x-ray structures of sialidase, human Neu2 PMID: 15501818
    9. propose that this Asian-enriched sialidase variation caused by the SNP, likely in homozygous form, may be associated with certain severe adverse reactions to oseltamivir PMID: 17426694
    10. Neu2 loss of expression might exacerbate the defective myogenic differentiation of rhabdomyosarcoma cells. PMID: 19524683

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  • 亞細(xì)胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Glycosyl hydrolase 33 family
  • 組織特異性：
    Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7759

    OMIM: 605528

    KEGG: hsa:4759

    STRING: 9606.ENSP00000233840

    UniGene: Hs.532681