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NSUN3 Antibody, HRP conjugated

  • 中文名稱：
    NSUN3兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA867156LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) NSUN3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    NSUN3
  • 別名：
    6720484A09Rik antibody; AU022521 antibody; FLJ22109 antibody; FLJ22609 antibody; MST077 antibody; MSTP077 antibody; NOL1/NOP2/Sun domain family 3 antibody; NOL1/NOP2/Sun domain family member 3 antibody; NOP2/Sun domain family member 3 antibody; NSUN3 antibody; NSUN3_HUMAN antibody; OTTMUSP00000028633 antibody; Putative methyltransferase NSUN3 antibody; UG0651E06 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial protein (1-200AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation.
  • 基因功能參考文獻(xiàn)：
    1. The authors show that the RNA methyltransferase NSUN3 localises to mitochondria and interacts with mt-tRNA(M)(et) to methylate cytosine 34 (C34) at the wobble position. PMID: 27497299
    2. The NSUN3-knockout cells showed strong reduction in mitochondrial protein synthesis and reduced oxygen consumption, leading to deficient mitochondrial activity. It reconstituted formation of 5-methylcytidine (m(5)C) at position 34 (m(5)C34) on mt-tRNA(Met) with recombinant NSUN3 in the presence of AdoMet, demonstrating that NSUN3-mediated m(5)C34 formation initiates f(5)C34 biogenesis. PMID: 27214402
  • 相關(guān)疾?。?/div>
    Mitochondrial complex deficiency (PubMed:27356879). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected (PubMed:27356879). Clinical features include combined developmental disability, microcephaly, failure to thrive, recurrent increased lactate levels in plasma, muscular weakness, proximal accentuated, external ophthalmoplegia and convergence nystagmus (PubMed:27356879). Defects are probably caused by deficient methylation and formylation of mt-tRNA(Met) wobble cytosine (PubMed:27356879). The disease may be caused by mutations affecting the gene represented in this entry.
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 26208

    OMIM: 617491

    KEGG: hsa:63899

    STRING: 9606.ENSP00000318986

    UniGene: Hs.436594