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  4. PCP4 Antibody

PCP4 Antibody

  • 中文名稱：
    PCP4兔多克隆抗體
  • 貨號：
    CSB-PA017636HA01HU
  • 規(guī)格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PCP4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PCP4
  • 別名：
    Brain specific antigen PCP 4 antibody; Brain specific polypeptide PEP 19 antibody; Brain specific polypeptide PEP19 antibody; Brain-specific antigen PCP-4 antibody; Brain-specific polypeptide PEP-19 antibody; OTTHUMP00000109191 antibody; Pcp4 antibody; PCP4_HUMAN antibody; PEP19 antibody; Purkinje cell protein 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Calmodulin regulator protein PCP4 protein (1-62AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PCP4 Antibody (CSB-PA017636HA01HU)，的標記方式是Non-conjugated。對于PCP4 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017636HB01HU PCP4 Antibody, HRP conjugated ELISA
    FITC CSB-PA017636HC01HU PCP4 Antibody, FITC conjugated
    Biotin CSB-PA017636HD01HU PCP4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways.
  • 基因功能參考文獻：
    1. PCP4 promoter was one of the most hypomethylated in aldosterone-producing adenoma and PCP4 transcription may be associated with demethylation as well as with CEBPA in APAs. PMID: 29294065
    2. PCP4/PEP19 has a role in promoting migration, invasion and adhesion in human breast cancer cells PMID: 27384474
    3. Data indicated that PCP4/PEP19 regulates apoptosis but exact mechanism is still unknown. PMID: 25153723
    4. PCP4 protein is highly expressed in the olfactory bulb and caudate putamen and PCP4 expressing cells in the brain are of neuronal origin. PMID: 24954028
    5. PCP4 is a regulator of aldosterone production in normal, hyperplastic, and neoplastic human adrenocortical cells. PMID: 24403568
    6. This study demonstrate that Pcp4 overexpression extended these effects later in development by modulating genes in line with the maturation of neurons in the cerebellum. PMID: 24291518
    7. The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release. PMID: 23204517
    8. Data show that Pcp4 overexpression induces precocious neuronal differentiation, and is associated with an increase in CaMKIIdelta activation. PMID: 21491429
    9. The PCP4 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    10. PEP-19 has the potential to alter the Ca2+-binding dynamics of free CaM and CaM that is bound to other target proteins PMID: 14551202

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  • 蛋白家族：
    PCP4 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8742

    OMIM: 601629

    KEGG: hsa:5121

    STRING: 9606.ENSP00000329403

    UniGene: Hs.80296