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  4. PIK3R6 Antibody, HRP conjugated

PIK3R6 Antibody, HRP conjugated

  • 中文名稱：
    PIK3R6兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA719469LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PIK3R6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C17orf38 antibody; Chromosome 17 open reading frame 38 antibody; HsT41028 antibody; p84 PI3K adapter protein antibody; p84 PIKAP antibody; p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein antibody; p87 PI3K adapter protein antibody; p87PIKAP antibody; Phosphatidylinositol 3-kinase; regulatory subunit 6 antibody; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa antibody; Phosphoinositide 3-kinase regulatory subunit 6 antibody; PI3Kgamma adapter protein of 87 kDa antibody; PI3R6_HUMAN antibody; PIK3R6 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Phosphoinositide 3-kinase regulatory subunit 6 protein (566-667AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.
  • 基因功能參考文獻：
    1. Our findings suggest that p84 binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity. PMID: 25753393
    2. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
    3. knockdown of p84 in MDA-MB-231 cells enhanced Akt phosphorylation and lung colonization PMID: 21996737
    4. p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP] PMID: 16476736
    5. ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells PMID: 18323525
    6. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma PMID: 18596232

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 27101

    OMIM: 611462

    KEGG: hsa:146850

    UniGene: Hs.255809