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  4. PSME4 Antibody, FITC conjugated

PSME4 Antibody, FITC conjugated

  • 中文名稱：
    PSME4兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA618917LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PSME4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PSME4
  • 別名：
    KIAA0077 antibody; PA200 antibody; Proteasome Activator 200 kDa antibody; Proteasome activator complex subunit 4 antibody; Proteasome activator PA200 antibody; PSME 4 antibody; psme4 antibody; PSME4_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Proteasome activator complex subunit 4 protein (105-198AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
  • 基因功能參考文獻(xiàn)：
    1. identified a novel 200 kDa nuclear protein that activates the proteasome; findings implicate PA200 in DNA repair, possibly by recruiting proteasomes to double strand breaks PMID: 12093752
  • 亞細(xì)胞定位：
    Cytoplasm, cytosol. Nucleus. Nucleus speckle. Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2).
  • 蛋白家族：
    BLM10 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20635

    OMIM: 607705

    KEGG: hsa:23198

    STRING: 9606.ENSP00000384211

    UniGene: Hs.413801