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RHOU Antibody

  • 中文名稱：
    RHOU兔多克隆抗體
  • 貨號：
    CSB-PA745331LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA745331LA01HU diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA745331LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA745331LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RHOU Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RHOU
  • 別名：
    ARHU antibody; CDC42 L1 antibody; CDC42 like GTPase antibody; CDC42-like GTPase 1 antibody; CDC42L1 antibody; G28K antibody; GTP binding protein like 1 antibody; GTP binding protein SB128 antibody; GTP-binding protein-like 1 antibody; hG28K antibody; mG28K antibody; Ras homolog gene family member U antibody; Ras homolog gene family member U isoform CRA a antibody; Ras like gene family member U antibody; Rho GTPase like protein ARHU antibody; Rho GTPase-like protein ARHU antibody; Rho related GTP binding protein RhoU antibody; Rho-related GTP-binding protein RhoU antibody; Rhou antibody; RHOU_HUMAN antibody; Ryu GTPase antibody; Wnt-1 responsive Cdc42 homolog 1 antibody; Wnt1 responsive Cdc42 homolog antibody; WRCH 1 antibody; WRCH-1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Rho-related GTP-binding protein RhoU protein (1-48AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，RHOU Antibody (CSB-PA745331LA01HU)，的標(biāo)記方式是Non-conjugated。對于RHOU Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA745331LB01HU RHOU Antibody, HRP conjugated ELISA
    FITC CSB-PA745331LC01HU RHOU Antibody, FITC conjugated
    Biotin CSB-PA745331LD01HU RHOU Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
  • 基因功能參考文獻(xiàn)：
    1. These results unravel a role for RhoU not only in regulating the migratory features of malignant plasma cells, but also in controlling cell cycle progression. PMID: 29440639
    2. This review addresses the developmental roles of 2 GTPases of the Rho family, RhoV/Chp and RhoU/Wrch. PMID: 26555387
    3. PAK4 and RhoU cooperate to drive adhesion turnover and promote cell migration. PMID: 26598620
    4. Data indicate that upregulated miR-126 upon coxsackievirus B3 (CVB3) infection targets SPRED1, LRP6, and WRCH1 genes, mediating cross-talk between ERK1/2 and Wnt/beta-catenin pathways, and thus promoting viral replication. PMID: 23811937
    5. multiple upstream signals may converge on Wrch1 directly through its SH3 domain-binding properties PMID: 23183748
    6. results indicate that NOTCH1 mutation stimulates T-cell acute lymphoblastic leukaemia cell migration through RhoU upregulation that could contribute to the leukaemia cell dissemination PMID: 22349824
    7. data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor signaling with RhoU activatio PMID: 21508312
    8. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. PMID: 21565175
    9. Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src. PMID: 20547754
    10. Down regulation of WRCH1 by estradiol in breast cancer and altered expression of WRCH1 is associated with other cancers PMID: 11894124
    11. G28K cDNA encodes a protein of 258 amino acids with homology to the cell division cycle 42/G25K protein; this gene is located at 1q42.11-q42.3; G28K was abundantly expressed in the stomach and the small intestine PMID: 14731133
    12. These data suggest that Wrch-1 regulates cell migration by multiple mechanisms: on the one hand Wrch-1 controls focal adhesions by regulating myosin light chain and on the other hand Wrch-1 stimulates the activation of Akt and JNK. PMID: 17504809
    13. Wrch-1-induced morphological and growth transformation may occur in part through Par6-mediated disruption of tight junction and actin organization. PMID: 19064640
    14. As an essential actor of osteoclast differentiation, the atypical RhoGTPase Wrch1/RhoU could be an interesting target for the development of novel antiresorptive drugs. PMID: 19135548

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 組織特異性：
    Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17794

    OMIM: 606366

    KEGG: hsa:58480

    STRING: 9606.ENSP00000355652

    UniGene: Hs.647774