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RND1 Antibody, Biotin conjugated

  • 中文名稱：
    RND1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA835694LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RND1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RND1
  • 別名：
    ARHS antibody; FLJ42294 antibody; GTP binding protein RHO6 antibody; Ras homolog gene family member S antibody; RHO 6 antibody; Rho family GTPase 1 antibody; Rho related GTP binding protein Rho6 antibody; RHO S antibody; Rho-related GTP-binding protein Rho6 antibody; RHO6 antibody; RHOS antibody; RND 1 antibody; Rnd1 antibody; RND1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Rho-related GTP-binding protein Rho6 protein (1-106AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
  • 基因功能參考文獻(xiàn)：
    1. Reduced RND1 expression in HCC was associated with cancer progression, likely through regulation of the Ras signaling pathway. PMID: 27770342
    2. Studies suggest that Rho GTPase signalling is a complicated mechanism in RhoA-driven cancer cell invasive migration. PMID: 27913679
    3. RND1 plays an important role in the progression of esophageal squamous cell carcinoma PMID: 26250459
    4. These results reveal a previously unappreciated mechanism through which Rnd1 restrains activation of Ras-MAPK signalling and breast tumour initiation and progression PMID: 25531777
    5. Data indicate that Rnd1 efficiently displaces Rac1 from its complex with Plexin-B1 but not vice versa. PMID: 23603360
    6. role of the N-terminal region in signaling; Rnd1 and Rnd3 have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant; the sequence mediates lipid raft targeting of p190 RhoGAP correlated with its activation PMID: 22357615
    7. Rnd1 does not play a role in the activation of plexin-C1 and -D1 PMID: 21610070
    8. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers PMID: 11940653
    9. The RND1 mRNA expression levels increased significantly after gestation in myometria. PMID: 16311049
    10. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain PMID: 17916560

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 組織特異性：
    Mostly expressed in brain and liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18314

    OMIM: 609038

    KEGG: hsa:27289

    STRING: 9606.ENSP00000308461

    UniGene: Hs.124940