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  4. ST6GALNAC3 Antibody, HRP conjugated

ST6GALNAC3 Antibody, HRP conjugated

  • 中文名稱：
    ST6GALNAC3兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA836724LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ST6GALNAC3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ST6GALNAC3
  • 別名：
    ST6GALNAC3 antibody; SIAT7C antibody; UNQ2787/PRO7177Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 antibody; EC 2.4.99.7 antibody; GalNAc alpha-2,6-sialyltransferase III antibody; ST6GalNAc III antibody; ST6GalNAcIII antibody; STY antibody; Sialyltransferase 7C antibody; SIAT7-C antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 protein (40-305AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity.
  • 基因功能參考文獻(xiàn)：
    1. genome-wide association study in population in Finland: Data suggest that one SNP in ST6GALNAC3 (rs12144344) and two SNPs in VDBP (vitamin D binding protein; rs7041, rs705117) are associated with serum levels of VDBP in the male population studied. PMID: 24740207
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20421487
    4. Results describe the molecular cloning and expression of human ST6GalNAc III, including its tissue distribution and substrate specificity. PMID: 16169874
    5. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826

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  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 組織特異性：
    Expressed in brain and kidney. Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19343

    OMIM: 610133

    KEGG: hsa:256435

    STRING: 9606.ENSP00000329214

    UniGene: Hs.337040