STYX Antibody, Biotin conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) STYX Polyclonal antibody
Uniprot No.：

Q8WUJ0
基因名：

STYX
別名：

Protein tyrosine phosphatase like protein antibody; Protein tyrosine phosphatase-like protein antibody; Serine/threonine/tyrosine interacting protein antibody; Serine/threonine/tyrosine-interacting protein antibody; Styx antibody; STYX_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Serine/threonine/tyrosine-interacting protein (1-223AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates. Plays a role in spermatogenesis.
基因功能參考文獻(xiàn)：
1. The authors show that STYX binds to the F-box domain of FBXW7 and disables its recruitment into the SCF ubiquitin ligase complex. PMID: 28007894
2. Results suggest that STYX is a pseudophosphatase that uses the 'competitor' and 'anchor' mode of action to exert its biologic roles. [review] PMID: 28408485
3. results identify STYX as an important regulator of ERK1/2 signaling critical for cell migration PMID: 23847209
亞細(xì)胞定位：

Nucleus. Cytoplasm, cytosol.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class subfamily
數(shù)據(jù)庫鏈接：

HGNC: 11447

OMIM: 615814

KEGG: hsa:6815

STRING: 9606.ENSP00000346599

UniGene: Hs.364980