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  4. TAF9 Antibody

TAF9 Antibody

  • 中文名稱：
    TAF9兔多克隆抗體
  • 貨號：
    CSB-PA619078ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: MCF-7 whole cell lysate, 293T whole cell lysate, Hela whole cell lysate, K562 whole cell lysate, A431 whole cell lysate
      All lanes: AK6 antibody at 0.59μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 21, 20 kDa
      Observed band size: 21 kDa
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA619078ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA619078ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TAF9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TAF9
  • 別名：
    TAF9 antibody; TAF2G antibody; TAFII31 antibody; Transcription initiation factor TFIID subunit 9 antibody; RNA polymerase II TBP-associated factor subunit G antibody; STAF31/32 antibody; Transcription initiation factor TFIID 31 kDa subunit antibody; TAFII-31 antibody; TAFII31 antibody; Transcription initiation factor TFIID 32 kDa subunit antibody; TAFII-32 antibody; TAFII32 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription initiation factor TFIID subunit 9 protein (1-264AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
  • 基因功能參考文獻：
    1. TAF9 directly binds HCA587/MAGEC2 through its CR domain, suggesting that HCA587/MAGEC2 may involve in TAF9 binding with DNA to regulate certain genes transcription. PMID: 29257297
    2. findings suggest that p53 sequesters TAF9 from GLI1, which may contribute to inhibition of GLI1 activity by p53 PMID: 26282181
    3. TAF9 depletion severely disrupts TFIID, indicating that the observed ongoing transcription is initiated with at least partially TAF-free TATA-binding protein. PMID: 12837753
    4. IL-1-inducible phosphorylation of p65 NFkB is mediated by multiple protein kinases including IKKalpha, IKKbeta, IKKepsilon, TBK1, and an unknown kinase and couples p65 to TAFII31-mediated IL-8 transcription PMID: 15489227
    5. suggest a novel STAF65gamma-dependent function of STAGA-type complexes in cell proliferation and transcription activation by MYC postloading of TFIID and RNA polymerase II that involves direct recruitment of core Mediator PMID: 17967894
    6. TAF9 functionally supports EKLF activity by enhancing its ability to activate the beta-globin gene. TAF9 interacts with a conserved beta-globin downstream promoter element PMID: 19251649
    7. Multiple hTAF(II)31-binding motifs in the intrinsically unfolded transcriptional activation domain of VP16. PMID: 19643037

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    TAF9 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11542

    OMIM: 600822

    KEGG: hsa:6880

    STRING: 9606.ENSP00000217893

    UniGene: Hs.653163