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TIE1 Antibody

  • 中文名稱：
    TIE1兔多克隆抗體
  • 貨號：
    CSB-PA07369A0Rb
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA07369A0Rb at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA07369A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TIE1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    JKT 14 antibody; JTK14 antibody; TIE antibody; Tie1 antibody; TIE1_HUMAN antibody; Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 antibody; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains antibody; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody; Tyrosine protein kinase receptor Tie 1 antibody; Tyrosine-protein kinase receptor Tie-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tyrosine-protein kinase receptor Tie-1 protein (217-328AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TIE1 Antibody (CSB-PA07369A0Rb)，的標記方式是Non-conjugated。對于TIE1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA07369B0Rb TIE1 Antibody, HRP conjugated ELISA
    FITC CSB-PA07369C0Rb TIE1 Antibody, FITC conjugated
    Biotin CSB-PA07369D0Rb TIE1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
  • 基因功能參考文獻：
    1. We identified colorectal cancer as a novel Tie1-expressing tumor, with Tie1-positive cells hardly detectable in the normal intestine. Tie1 expression did not influence cancer cell proliferation in regular in vitro cultures, but significantly affected malignant growth of transplanted tumors in vivo. PMID: 28464467
    2. T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures, but did not alter Tie1 or Tie2 tyrosine phosphorylation or downstream signaling. PMID: 26436659
    3. The decreasing expression of Tie1 may play an important role in the pathogenesis of primary lower extremity varicose veins. PMID: 22987233
    4. Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours. PMID: 22421998
    5. The Tie-1 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components. PMID: 20164029
    6. A natural antisense transcript was identified for tyrosine kinase containing immunoglobulin and epidermal growth factor homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans. PMID: 19880500
    7. high expression independently associated with shorter survival in patients with early chronic phase CML PMID: 11920509
    8. Overexpression and activation of Tie1 is associated with breast and colonic neopalsms PMID: 17786322
    9. the trophoblastic shell of the very early human placenta, as well as endothelial cells and ACC exhibited strong staining intensity for Tie-1 PMID: 18675456
    10. Tie-1 has an inflammatory function in endothelial cells. PMID: 19236867

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
  • 組織特異性：
    Specifically expressed in developing vascular endothelial cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11809

    OMIM: 600222

    KEGG: hsa:7075

    STRING: 9606.ENSP00000361554

    UniGene: Hs.78824