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  4. VDAC3 Antibody, Biotin conjugated

VDAC3 Antibody, Biotin conjugated

  • 中文名稱：
    VDAC3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA896484LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) VDAC3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3), VDAC3
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Voltage-dependent anion-selective channel protein 3 protein (40-160aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
  • 基因功能參考文獻：
    1. The AG genotype of rs16891278 showed a significantly lower sperm concentration compared with the AA genotype (P = 0.044). Findings suggest that VDAC3 genetic variants may be associated with human sperm count. PMID: 28431403
    2. This cohort study showed that the VDAC3 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID: 28916538
    3. VDAC3 is able to modulate its pore size and current by exploiting the mobility of the N-terminal and forming, upon external stimuli, disulfide bridges with cysteine residues located on the barrel and exposed to the inter-membrane space. PMID: 26806159
    4. channel gating of VDAC3 might be controlled by redox sensing under physiological conditions PMID: 26407725
    5. observed electrophysiological properties of hVDAC3 are surprisingly different from the other isoforms and are discussed in relation to the proposed physiological role of the protein in mammalian cells PMID: 25171321
    6. a VDAC3-Mps1 module at the centrosome promotes ciliary disassembly during cell cycle entry. PMID: 23388454
    7. VDAC3 is present at the mother centriole and modulates centriole assembly by recruiting Mps1 to centrosomes. PMID: 22935710
    8. VDAC3 has a limited ability to support mitochondrial respiration and has no influence in the control of ROS production. PMID: 20138821
    9. VDAC3 is a novel target for protein S-nigrosylation in spermatozoa. PMID: 17683036

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  • 亞細胞定位：
    Mitochondrion outer membrane. Membrane.
  • 蛋白家族：
    Eukaryotic mitochondrial porin family
  • 組織特異性：
    Expressed in erythrocytes (at protein level). Widely expressed. Highest in testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12674

    OMIM: 610029

    KEGG: hsa:7419

    STRING: 9606.ENSP00000428845

    UniGene: Hs.699301