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  4. ZMAT3 Antibody

ZMAT3 Antibody

  • 中文名稱：
    ZMAT3兔多克隆抗體
  • 貨號：
    CSB-PA942507
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA942507(ZMAT3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA942507(ZMAT3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ12296 antibody; FLJ31683 antibody; MGC10613 antibody; OTTHUMP00000211906 antibody; OTTHUMP00000211907 antibody; p53 activated gene 608 antibody; p53 inducible zinc finger protein antibody; p53 target zinc finger protein antibody; p53-activated gene 608 protein antibody; PAG 608 antibody; WIG 1 antibody; WIG 1/PAG608 protein antibody; WIG1 antibody; WIG1/PAG608 protein antibody; Wildtype p53-induced gene antibody; Zinc finger matrin type 3 antibody; Zinc finger matrin-type protein 3 antibody; Zinc finger protein WIG 1 antibody; Zinc finger protein WIG-1 antibody; Zinc finger protein WIG1 antibody; ZMAT 3 antibody; Zmat3 antibody; ZMAT3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ZMAT3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.
  • 基因功能參考文獻：
    1. WIG1 governs the miRNA-dependent and the miRNA-independent recruitment of AGO2 to lower the stability of and suppress the translation of ACOT7 mRNA. PMID: 28472401
    2. we propose that Wig1, a key p53 downstream molecule in HD condition, play an important role in stabilizing mutant Htt mRNA and thereby accelerating HD pathology in the mHtt-p53-Wig1 positive feedback manner PMID: 27206983
    3. expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma PMID: 25379706
    4. Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels. PMID: 24469038
    5. PSF and MATR3 are cellular host factors that bind viral RNA and promote Rev activity. PMID: 23158102
    6. The data indicated a novel role for Wig1 in RNA-induced silencing complex target accessibility, which is a key step in RNA-mediated gene silencing. Fine tuning of p21 levels by Wig1 was essential for the prevention of cellular senescence. PMID: 23085987
    7. Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc. PMID: 22513872
    8. WIG-1 might be involved in the zinc-induced cell cycle arrest and apoptosis of human esophageal squamous cell carcinoma cells PMID: 21559779
    9. WIG-1 might be a novel modifier in esophageal carcinogenesis, and the WIG-1 MAb should be useful in further study of the mechanism in WIG-1-related physiological reactions. PMID: 21050045
    10. The cellular distribution of the nuclear matrix protein matrin 3 is altered by novel phosphorylation induced by the alphaherpesvirus US3 kinase family. PMID: 20962082
    11. Results demonstrate that human Wig-1 can bind different types of double-stranded RNAs (dsRNAs), including dsRNAs resembling small interfering RNAs and microRNAs, and indicate that dsRNA binding has a role in Wig-1-mediated regulation of cell growth. PMID: 16844115
    12. Wig-1-binding proteins, hnRNP A2/B1 and RNA Helicase A, both of which are involved in RNA processing, were identified. PMID: 18519039
    13. Data demonstrated a direct interaction between Dicer and Wig-1 and both may play a common role in dsRNA-related gene regulation. PMID: 19127773
    14. the p53 target Wig-1 is a previously undescribed AU-rich element-regulating protein that acts as a positive feedback regulator of p53, with implications both for the steady-state levels of p53 and for the p53 stress response PMID: 19805223

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  • 亞細胞定位：
    Nucleus. Nucleus, nucleolus.
  • 組織特異性：
    Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29983

    OMIM: 606452

    KEGG: hsa:64393

    STRING: 9606.ENSP00000311221

    UniGene: Hs.371609