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  4. Recombinant Bovine Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

Recombinant Bovine Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

  • 中文名稱：
    牛PPP2CA重組蛋白
  • 貨號：
    018559BO
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PPP2CA; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; EC 3.1.3.16
  • 免疫原種屬：
    Bos taurus (Bovine)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3.
  • 基因功能參考文獻：
    1. changes in PP2A activity due to methylation and tyrosine phosphorylation occur in sperm; these changes may play an important role in the regulation of sperm function PMID: 26569399
    2. The findings demonstrate an endothelial VEGF resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis. PMID: 24606881
  • 亞細胞定位：
    Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    PPP phosphatase family, PP-1 subfamily
  • 數(shù)據(jù)庫鏈接：