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  4. Recombinant Mouse Iroquois-class homeodomain protein IRX-3 (Irx3), partial

Recombinant Mouse Iroquois-class homeodomain protein IRX-3 (Irx3), partial

  • 中文名稱：
    小鼠Irx3重組蛋白
  • 貨號：
    011835MO1
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    Irx3
  • 別名：
    Irx3; Irxb1; Iroquois-class homeodomain protein IRX-3; Homeodomain protein IRXB1; Iroquois homeobox protein 3
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應(yīng)用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
  • 基因功能參考文獻：
    1. Irx3 is necessary for the postnatal maturation of the VCS, possibly via its interactions with Tbx5 and Nkx2.5. PMID: 26786475
    2. Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1. PMID: 24726282
    3. data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition PMID: 24646999
    4. postnatal Irx3 activity can be repressed by Irx5 PMID: 22992950
    5. Irx3 is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-forming connexins PMID: 21825130
    6. Irx3 signal is restricted to the somatic cell component of XX gonads and is present at a discreet period of ovarian development that ends at birth. PMID: 15963769

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 組織特異性：
    Expressed by neural progenitor cells in discrete domains of the ventral neural tube. Also expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is confi
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