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  4. Recombinant Mouse Tubulin alpha-1A chain (Tuba1a)

Recombinant Mouse Tubulin alpha-1A chain (Tuba1a)

  • 中文名稱：
    小鼠Tuba1a重組蛋白
  • 貨號(hào)：
    025306MO
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Tuba1a; Tuba1; Tubulin alpha-1A chain; Alpha-tubulin 1; Alpha-tubulin isotype M-alpha-1; Tubulin alpha-1 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應(yīng)用說(shuō)明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲(chǔ)存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻(xiàn)：
    1. Here the authors demonstrate that mice lacking the alpha-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli. PMID: 27976998
    2. Collectively, these findings suggest that Smo and primary cilia-dependent noncanonical Hh signaling leads to post-translational regulation of microtubules and may be important for modulating cell behaviors. PMID: 27793670
    3. Further PS treatment resulted in recovery of axonal outgrowth and enhanced retrograde axonal transport by decreasing histone deacetylase 6 (HDAC6) levels and thus increasing acetylation of alpha-tubulin levels. Thus, we have identified the molecular pathway that leads to neurodegeneration in FD and have demonstrated that phosphatidylserine treatment has the potential to slow progression of neurodegeneration PMID: 27997532
    4. mass spectrometry-based quantitative comparison of acetylated peptides from wild-type vs HDAC6 knockout mice allowed to identify six new deacetylation sites possibly mediated by HDAC6. PMID: 26581825
    5. These results give new insights into the functions of Tuba1a, mechanisms for regulating tubulin proteostasis, and how compromising these may lead to neural defects. PMID: 26658218
    6. Data indicate that alpha 1a tubulin (Tuba1a) showed the least variability in expression among the different stages of lung development. PMID: 25723738
    7. Tubulin-tyrosine ligase (TTL) is required to increase the levels of tyrosinated alpha-tubulin at the axon injury site and plays an important role in injury signaling. PMID: 25911101
    8. Data suggest a mechanistic link between tubulin hyperacetylation and autophagy induction. PMID: 25404307
    9. TFIIB co-localizes and interacts with alpha-tubulin during oocyte meiosis in the mouse and depletion of TFIIB causes arrest of subsequent embryo development. PMID: 24244602
    10. Acetylation of alpha-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells. PMID: 23126280
    11. Unambiguous identification of novel glutamylation sites E441 and E443 in mouse brain Tuba1a and Tuba1b. PMID: 22296162
    12. This study demonistrated that novel tubal(aspartic acid to glycine) mutant mouse is a novel animal model for neurodevelopmental disorders. PMID: 22101068
    13. These results demonstrate a role for CCP1 in the processing of Glu residues from beta- as well as alpha-tubulin in vitro and in vivo. PMID: 22170066
    14. Our results highlight the importance of Tuba1a for correct neuronal migration PMID: 21875651
    15. association between dysferlin and alpha-tubulin, as well as between dysferlin and microtubules PMID: 20405035
    16. mice harbouring an S140G mutation in Tuba1a present with normal neurogenic potential, but that this neurogenesis is often ectopic PMID: 21041996
    17. Data indicated that CacyBP/SIP could simultaneously interact with tubulin and actin, suggesting that CacyBP/SIP might link actin and tubulin cytoskeletons. PMID: 20637809
    18. Data support a model in which stathmin functions in interphase to control the partitioning of tubulins between dimer and polymer pools by setting the number of microtubules per cell. PMID: 19515833
    19. Mutations in alpha-tubulin in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with associated behavioral deficits. PMID: 17218254
    20. Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. PMID: 17360631
    21. The results uncover alpha-tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons. PMID: 19185337

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    Ubiquitously expressed, although primarily in lung and brain.
  • 數(shù)據(jù)庫(kù)鏈接：