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  4. Recombinant Mouse TNF receptor-associated factor 5 (Traf5)

Recombinant Mouse TNF receptor-associated factor 5 (Traf5)

  • 中文名稱：
    小鼠Traf5重組蛋白
  • 貨號：
    024153MO
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Traf5; TNF receptor-associated factor 5
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應(yīng)用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
  • 基因功能參考文獻(xiàn)：
    1. TRAF5 is crucially involved in OSM-mediated lung inflammation probably by inducing lung stromal/fibroblast cell activation. PMID: 29596835
    2. our data indicate that Berberine exerts protective effects against chronic renal failurepartly through the TRAF5-mediated activation of the NF-kappaB signaling pathway in mouse podocytes PMID: 29115406
    3. The results indicated that TRAF5 deficiency significantly aggravated DSS-induced colitis, most likely by regulating Th cell-mediated inflammation. PMID: 27110068
    4. In conclusion, our results suggest that as an intrinsic cardioprotective factor, TRAF5 plays a crucial role in the development of cardiac hypertrophy through the negative regulation of the MEK-ERK1/2 pathway PMID: 24038435
    5. knock-out mice develop exaggerated experimental autoimmune encephalomyelitis due to enhanced Th17 cell differentiation PMID: 24681564
    6. TRAF5 negatively regulates TLR signaling in B lymphocytes. PMID: 24259503
    7. These results provide the first demonstration that TRAF5 is a critical mediator of brain ischemia/reperfusion in an experimental stroke model. PMID: 23413803
    8. Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). PMID: 21822258
    9. TNF receptor-associated factor 5 (TRAF5) deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation. PMID: 20651286
    10. Study is the first report showing a major requirement for TRAF5 in signaling by a specific receptor both in vitro and in vivo, as well as playing an important role in biological function in B lymphocytes. PMID: 19805155
    11. role in both RANKL- and TNFalpha-induced osteoclastogenesis PMID: 12619928
    12. TRAF5 has a role in TNF-alpha induced IKK phosphorylation of NF-kappaB p65 PMID: 12842894
    13. TRAF5 plays a limiting role during the differentiation of type 2 helper (Th2) cells by limiting certain responses driven by costimulatory molecules such as OX40/CD134. PMID: 15034043
    14. Traf5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced TNFR in T-lymphocytes. PMID: 16452475
    15. TRAF5 as an important positive signaling element that enhances T cell expansion and pathogen containment by providing a survival advantage to responding Ag-specific CD8(+) T cells during infection. PMID: 19017969

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  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族：
    TNF receptor-associated factor family, A subfamily
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:22033

    UniGene: Mm.380491