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  4. Recombinant Mouse Semaphorin-3E (Sema3e)

Recombinant Mouse Semaphorin-3E (Sema3e)

  • 中文名稱：
    小鼠Sema3e重組蛋白
  • 貨號：
    020984MO
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    Sema3e
  • 別名：
    Sema3e; Semah; Semh; Semaphorin-3E; Semaphorin-H; Sema H
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 應(yīng)用說明：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 儲存條件：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation.
  • 基因功能參考文獻：
    1. Results describe new roles of Sema3E/PlexinD1 signaling during development and in adult hippocampal formation and provide evidence for an implication of Sema3E/PlexinD1 in the layer-specific development of the entorhino-hippocampal connection. PMID: 29358640
    2. that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogenesis PMID: 28646017
    3. The data indicate that exposure to house dust mite markedly reduces Sema3E expression in mouse airways. More important, replenishment of Sema3E by intranasal administration of exogenous Sema3E protects mice from allergic asthma by reducing eosinophilic inflammation, serum IgE level, and T helper cell 2/T helper cell 17 cytokine response. PMID: 28634005
    4. findings identify Sema3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events and suggest that targeting this molecule could be a novel approach to treat allergic asthma. PMID: 28108561
    5. Our results demonstrate that sema3e/plexin D1 modulates IS formation and Ag-scanning activities of thymocytes within thymic tissues. PMID: 26921307
    6. these results identify SEMA3E as an essential gene for GnRH neuron development, uncover a neurotrophic function for SEMA3E in the developing brain PMID: 25985275
    7. Sema3E is a natural negative regulator of the migration of PlexinD1-positive Cajal-Retzius (CR) cells originating in the cortical hem. Sema3E/PlexinD1 signaling controls the motogenic potential of CR cells in vitro and in vivo. PMID: 24969029
    8. Our results indicate that Sema3e, secreted by damaged hepatocytes, affects sinusoidal regeneration in a paracrine manner during liver regeneration PMID: 24930441
    9. Semaphorin 3d requires neuropilin 1 or PI3K/Akt, whereas semaphorin 3e requires plexin D1 in directing endothelial motility. PMID: 24825896
    10. Proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools. PMID: 24210822
    11. Sema3E acts as a chemoattractant for macrophages, with p53-induced upregulation of Sema3E expression provoking adipose tissue inflammation and systemic insulin resistance in association with dietary obesity. PMID: 24093674
    12. beta1 integrin adhesion is controlled by the plexinD1-sema3E axis in mice PMID: 24344262
    13. Sema3E(-) (/) (-) mice survive throughout development and into adulthood, despite severe initial vascular defects. PMID: 23444297
    14. Sema3E mRNA was highly downregulated in plaque macrophages PMID: 23430613
    15. Sema3e is a novel inhibitor of osteoclast formation in vitro and may play a role in maintaining local bone homeostasis PMID: 22227882
    16. Sema3E-generated avascular zones are critical regulators of mammalian cardiovascular patterning and are the first to identify a repulsive role for the lateral plate mesoderm. PMID: 22076636
    17. This study demonstrated that Sema3E and Plexin-D1 specify the degree of glutamatergic connectivity between a specific source and target in the complex circuitry of the basal ganglia. PMID: 22179111
    18. a novel role of Sema3E-Plexin-D1 function in modulating angiogenesis via a VEGF-induced feedback mechanism PMID: 21724832
    19. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice PMID: 21505259
    20. Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. PMID: 20385769
    21. Results indicate that inhibition of Sema3E may be a novel strategy for therapeutic angiogenesis,especially when VEGF is ineffective. PMID: 19940264
    22. signaling by semaphorin 3E and its receptor plexin-D1 controls endothelial cell positioning and the patterning of the developing vasculature in the mouse PMID: 15550623
    23. In the mouse cortex, two significant differences were observed in the pattern of Sema3E mRNA distribution. 1) Sema3E mRNA was expressed in layer Vb, in addition to layer VI in mice. 2) A subset of GABAergic interneurons expressed Sema3E mRNA in mice. PMID: 16977617
    24. Our data reveal a "gating" function of neuropilin-1 in semaphorin3e-plexinD1 signaling during the assembly of forebrain neuronal circuits PMID: 18054858
    25. Rnd2 bound to Plexin-D1 in cortical neurons, and Sema3E/Plexin-D1-induced inhibition of axon outgrowth of cortical neurons required Rnd2 and down-regulation of R-Ras activity. PMID: 19136556
    26. a recognition system involving expression of class 3 semaphorin Sema3e by selected motor neuron pools, and its high-affinity receptor plexin D1 by proprioceptive sensory neurons, is a critical determinant of synaptic specificity in sensory-motor circuits PMID: 19421194

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Semaphorin family
  • 組織特異性：
    Detected in neurons in the thalamus. Detected in embryonic vasculature. Developing lungs, developing skeletal elements and ventral horns of the developing neural tube. Correlates positively with tumor progression.
  • 數(shù)據(jù)庫鏈接：