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CD96 Recombinant Monoclonal Antibody

  • 中文名稱：
    CD96重組抗體
  • 貨號(hào)：
    CSB-RA004971A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of CD96 with anti-CD96 antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD96(CSB-MP004971HU1(F2)) at 2 μg/mL can bind Anti-CD96 recombinant antibody, the EC50 is 95.78-127.1 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD96 Recombinant Monoclonal Antibody（Code：CSB-RA004971A0HU）是一款高特異性抗體，靶向CD96分子——一種在免疫調(diào)節(jié)中起關(guān)鍵作用的跨膜蛋白。CD96作為免疫球蛋白超家族成員，主要在T細(xì)胞、NK細(xì)胞等免疫細(xì)胞表面表達(dá)，通過與其配體CD155的相互作用參與細(xì)胞間信號(hào)傳導(dǎo)，在腫瘤免疫逃逸、自身免疫性疾病等病理過程中具有研究價(jià)值。本產(chǎn)品采用重組技術(shù)制備，具有嚴(yán)格的批次間一致性，經(jīng)ELISA實(shí)驗(yàn)驗(yàn)證可特異性識(shí)別天然及重組CD96蛋白，適用于靶蛋白的定性或半定量檢測。在科研領(lǐng)域，該抗體可應(yīng)用于免疫細(xì)胞功能研究、腫瘤微環(huán)境分析、免疫檢查點(diǎn)調(diào)控機(jī)制探索等方向，例如通過ELISA檢測細(xì)胞培養(yǎng)上清或血清樣本中的CD96表達(dá)水平，為揭示其在免疫應(yīng)答中的作用提供可靠工具。產(chǎn)品僅限科研使用，不適用于臨床診斷或其他非研究用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD96; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD antigen CD96
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD96 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    4A4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
  • 基因功能參考文獻(xiàn)：
    1. Lower CD96 expression was also observed in human IL-9(+) compared with IFN-gamma(+) T cells PMID: 29531070
    2. Blocking CD96 or TIGIT with mAbs has been shown to improve tumor control in mice. PMID: 27620276
    3. CD96 and CD123 are expressed in bone marrow cells of patients with myelodysplastic syndromes PMID: 26642704
    4. In the present study we analyzed the expression of four cell surface antigens relevant to human hematopoiesis-CD90, CD96, CD117, and CD123-in bone marrow from pediatric acute myeloid leukemia patients and normal control subjects. PMID: 24751333
    5. down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course. PMID: 23272144
    6. CD96 could serve as a target structure for effector cell-mediated lysis. PMID: 22879978
    7. The positive expression of CD96 on bone marrow hematopoietic stem cells in patients with acute leukemia may be associated with primary drug resistance, relapse and progression. PMID: 21729528
    8. CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. PMID: 15034010
    9. CD96 is a cell surface marker present on many acute myeloid leukemia leukemic stem cells PMID: 17576927
    10. CD96-driven adhesion to CD155 may be crucial in developmental processes PMID: 19056733

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  • 相關(guān)疾?。?/div>
    C syndrome (CSYN)
  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16892

    OMIM: 211750

    KEGG: hsa:10225

    STRING: 9606.ENSP00000283285

    UniGene: Hs.142023