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CRTC3 Recombinant Monoclonal Antibody

  • 中文名稱：
    CRTC3重組抗體
  • 貨號：
    CSB-RA955619A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA955619A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CRTC3 Recombinant Monoclonal Antibody（Code: CSB-RA955619A0HU）是一款針對CRTC3蛋白開發(fā)的高特異性抗體。CRTC3（CREB-regulated transcription coactivator 3）是調(diào)控能量代謝和應激反應的關(guān)鍵分子，通過與CREB等轉(zhuǎn)錄因子相互作用參與脂肪代謝、糖異生及細胞分化等重要生物學過程。本抗體通過重組技術(shù)制備，經(jīng)ELISA和免疫組化（IHC）嚴格驗證，在IHC應用中推薦使用1:50-1:200稀釋比例，可清晰檢測組織樣本中CRTC3的定位與表達水平，具有優(yōu)異的信號特異性和批次穩(wěn)定性。該產(chǎn)品適用于研究CRTC3在代謝調(diào)控、脂肪細胞分化、肝臟功能及相關(guān)疾病模型中的作用機制，可為能量代謝通路研究、肥胖或糖尿病等代謝性疾病的基礎(chǔ)科研提供可靠工具，支持細胞生物學、分子病理學等領(lǐng)域的實驗需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3), CRTC3, TORC3
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human CRTC3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10G3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
  • 基因功能參考文獻：
    1. CRTC3-MAML2 gene fusion occurs in hidradenomas. PMID: 29079171
    2. CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism PMID: 29979427
    3. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker PMID: 28438292
    4. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma PMID: 27402217
    5. The CRTC3 polymorphism rs3862434 is associated with the plasma level of total cholesterol, and rs11635252 is associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population. PMID: 24264430
    6. Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement. PMID: 24121173
    7. mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases PMID: 21668476
    8. CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone PMID: 21536665
    9. As a common human CRTC3 variant with increased transcriptional activity is associated with adiposity in two distinct Mexican-American cohorts, results suggest that adipocyte CRTC3 may play a role in the development of obesity in humans PMID: 21164481
    10. Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion. PMID: 19749740
    11. transducer of regulated cyclic AMP-response element-binding protein 3 (TORC3), a co-activator of CREB, is involved in Tax-induced transcriptional activation from the HTLV-I LTR PMID: 15466468
    12. These results strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription. PMID: 16980408
    13. BCL3 functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with TORC3 PMID: 17644518
    14. study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. PMID: 18050304

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    TORC family
  • 組織特異性：
    Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26148

    OMIM: 608986

    KEGG: hsa:64784

    STRING: 9606.ENSP00000268184

    UniGene: Hs.567572