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CTPS1 Recombinant Monoclonal Antibody

  • 中文名稱：
    CTPS1重組抗體
  • 貨號：
    CSB-RA548305A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA548305A0HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CTPS1 Recombinant Monoclonal Antibody（CSB-RA548305A0HU）是針對胞苷三磷酸合成酶1（CTPS1）開發(fā)的高特異性科研試劑，該靶點作為嘧啶核苷酸生物合成通路中的關鍵限速酶，通過催化UTP轉化為CTP參與DNA/RNA合成，在細胞增殖調控及腫瘤發(fā)生發(fā)展中具有重要作用。本抗體采用重組技術制備，經ELISA和免疫組化（IHC）雙重驗證，在石蠟包埋組織切片中展現優(yōu)異的抗原識別能力，推薦使用濃度范圍為1:50至1:200時可獲得清晰的胞內定位信號，適用于檢測多種生物樣本中CTPS1蛋白的表達水平。憑借單克隆抗體特有的高批次一致性，該產品可為腫瘤生物學研究、細胞代謝機制探索以及增殖相關疾病模型的建立提供可靠工具，特別適用于癌癥發(fā)生機制、藥物靶點篩選和細胞周期調控等基礎研究領域。
  • Uniprot No.：
  • 基因名：
    CTPS1
  • 別名：
    CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1), CTPS1, CTPS
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human CTPS1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    13B6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
  • 基因功能參考文獻：
    1. CTP synthase forms the cytoophidium in human hepatocellular carcinoma. PMID: 29097181
    2. The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes. PMID: 28459447
    3. Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. PMID: 24477477
    4. results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response PMID: 24870241
    5. analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation PMID: 20739275
    6. CTP synthetase is phosphorylated by protein kinase A PMID: 16179339
    7. Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity. PMID: 17463002
    8. analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity PMID: 17681942
    9. studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization PMID: 18600551

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  • 相關疾病：
    Immunodeficiency 24 (IMD24)
  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    CTP synthase family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 2519

    OMIM: 123860

    KEGG: hsa:1503

    STRING: 9606.ENSP00000361699

    UniGene: Hs.473087