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GPRC5D Recombinant Monoclonal Antibody

  • 中文名稱：
    GPRC5D重組抗體
  • 貨號：
    CSB-RA882153MA01HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human GPRC5D with Anti-GPRC5D recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D(CSB-MP882153HU) at 5 μg/mL can bind Anti-GPRC5D recombinant antibody, the EC50 is 8.847-10.38 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA882153MA01HU GPRC5D重組單克隆抗體是針對G蛋白偶聯(lián)受體C5家族成員D亞型（GPRC5D）開發(fā)的高特異性科研工具。該受體作為細(xì)胞膜表面重要信號分子，在腫瘤微環(huán)境調(diào)控及多發(fā)性骨髓瘤等疾病中展現(xiàn)出潛在生物學(xué)意義。本產(chǎn)品經(jīng)ELISA平臺嚴(yán)格驗(yàn)證，表現(xiàn)出優(yōu)異的抗原結(jié)合能力與低交叉反應(yīng)性，可精準(zhǔn)識別天然及重組形式的目標(biāo)蛋白。采用重組表達(dá)技術(shù)制備的抗體具備優(yōu)異的批次穩(wěn)定性，為實(shí)驗(yàn)數(shù)據(jù)可重復(fù)性提供保障。適用于體外樣本中GPRC5D蛋白的定量檢測、細(xì)胞定位分析及分子互作研究，尤其在腫瘤生物學(xué)領(lǐng)域可助力探索受體介導(dǎo)的信號通路機(jī)制及其在疾病進(jìn)展中的作用?？蒲腥藛T可將其應(yīng)用于藥物靶點(diǎn)驗(yàn)證、腫瘤標(biāo)志物篩選等基礎(chǔ)研究場景，為開發(fā)新型治療策略提供可靠檢測手段。該產(chǎn)品僅限于科學(xué)研究使用，不適用于臨床診斷或其他非科研用途。
  • Uniprot No.：
  • 基因名：
  • 別名：
    GPRC5D; G-protein coupled receptor family C group 5 member D
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GPRC5D protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG4(S228P)
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    3D4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies. PMID: 23510526
    2. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. PMID: 22591013
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscl
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13310

    OMIM: 607437

    KEGG: hsa:55507

    STRING: 9606.ENSP00000228887

    UniGene: Hs.644599