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RGS6 Recombinant Monoclonal Antibody

  • 中文名稱：
    RGS6重組抗體
  • 貨號(hào)：
    CSB-RA253226A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA253226A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA253226A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of PC-3 cell with CSB-RA253226A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 592-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA253226A0HU RGS6重組單克隆抗體是針對RGS6蛋白開發(fā)的高特異性科研工具，適用于多種實(shí)驗(yàn)場景。該抗體靶向的RGS6（Regulator of G-protein Signaling 6）屬于RGS蛋白家族成員，通過加速Gα亞基GTP水解負(fù)調(diào)控G蛋白信號(hào)轉(zhuǎn)導(dǎo)，在神經(jīng)功能調(diào)控、氧化應(yīng)激反應(yīng)及腫瘤發(fā)生發(fā)展中發(fā)揮重要作用。經(jīng)ELISA、免疫組化（IHC）和免疫熒光（IF）嚴(yán)格驗(yàn)證，該抗體在1:50-1:200稀釋范圍內(nèi)表現(xiàn)出優(yōu)異性能，可清晰顯示目標(biāo)蛋白在細(xì)胞或組織中的亞定位特征，尤其適用于石蠟切片、冰凍切片及培養(yǎng)細(xì)胞樣本分析。實(shí)驗(yàn)數(shù)據(jù)顯示其對人類、小鼠和大鼠來源樣本具有高度交叉反應(yīng)一致性，背景信號(hào)低且重復(fù)性良好?？蒲腥藛T可將其應(yīng)用于神經(jīng)系統(tǒng)疾病模型、腫瘤微環(huán)境研究及心血管病理機(jī)制探索等領(lǐng)域，重點(diǎn)解析RGS6在疾病相關(guān)信號(hào)通路中的動(dòng)態(tài)變化及功能調(diào)控網(wǎng)絡(luò)，為神經(jīng)退行性疾病、癌癥耐藥性等研究提供可靠的蛋白檢測方案。
  • Uniprot No.：
  • 基因名：
    RGS6
  • 別名：
    Regulator of G-protein signaling 6 (RGS6) (S914), RGS6
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human RGS6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    12H5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.
  • 基因功能參考文獻(xiàn)：
    1. the results suggest that HA117 regulates the development of drug resistance in CT26 cells in vitro and in vivo. PMID: 28731026
    2. study shows that HA117 potentially promotes the stem-like signature of the HL60/ATRA cell line by inhibiting by the ubiquitination and degradation of DNMT1 and by down-regulating the expression of the GGL domain of RGS6 PMID: 28665981
    3. genetic association studies on a population in Republic of Korea: Data suggest that an SNP in RGS6 (rs2239219) is closely linked to stress-induced abdominal obesity in the population studied. PMID: 28090039
    4. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS6 in fine-tuning TRPC4 activities. PMID: 26987813
    5. Our results suggest that HA117 is a strong multidrug resistance gene. PMID: 20635168
    6. This suggests that HA117 might be an important resistance gene in pediatric solid tumors. PMID: 23619123
    7. No significant association between SNPs of RGS6 and central adiposity has been found. PMID: 26340433
    8. reduced RGS6 expression is associated with poor survival in colorectal cancer patients, suggesting that RGS6 expression may serve as an important prognostic marker PMID: 26653562
    9. these date demonstrate that RGS6 decreases in tumor tissue and may serve as a novel biomarker for outcomes in pancreatic cancer patients and be a potential therapeutic target potential therapeutic target. PMID: 25120791
    10. we found a novel mutation in RGS6, the splice-acceptor variant c.1369-1G>C that was not previously reported in congenital cataract phenotypes. PMID: 25525169
    11. genetic association studies in Hispanic-American families in Texas and Colorado: SNP in RGS6 are associated with high dietary fat intake, food preferences, and adiposity/obesity phenotype PMID: 21233807
    12. RGS6-induced apoptosis in both breast cancer cells and mouse embryonic fibroblasts does not require its GAP activity toward G proteins PMID: 21041304
    13. interacts with SCG10 and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of this protein PMID: 12140291
    14. Role of the RGS domain in stress-induced trafficking of RGS6 protein PMID: 12761220
    15. RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants PMID: 12761221
    16. RGS6 is the first member of the RGS protein family shown to interact with proteins involved in transcriptional regulation. PMID: 14734556

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  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Nucleus. Cell membrane.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10002

    OMIM: 603894

    KEGG: hsa:9628

    STRING: 9606.ENSP00000451030

    UniGene: Hs.509872