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  4. TMEFF2 Recombinant Monoclonal Antibody

TMEFF2 Recombinant Monoclonal Antibody

  • 中文名稱：
    TMEFF2重組抗體
  • 貨號：
    CSB-RA883439MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of TMEFF2 with Anti-TMEFF2 monoclonal antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TMEFF2 (CSB-MP883439HU) at 2 μg/mL can bind Anti-TMEFF2 recombinant antibody, the EC50 is 2.129-2.956 ng/mL.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA883439MA1HU TMEFF2重組單克隆抗體是針對跨膜蛋白TMEFF2開發(fā)的高特異性科研試劑，適用于ELISA檢測體系。該抗體采用重組表達(dá)技術(shù)制備，具有優(yōu)異的批間一致性和抗原識別準(zhǔn)確性，可精準(zhǔn)檢測樣本中TMEFF2蛋白的表達(dá)水平。TMEFF2作為重要的調(diào)控分子，在神經(jīng)系統(tǒng)發(fā)育、腫瘤發(fā)生及代謝調(diào)節(jié)中發(fā)揮關(guān)鍵作用，尤其在結(jié)直腸癌、前列腺癌等實體瘤中呈現(xiàn)異常表達(dá)特征。本產(chǎn)品經(jīng)嚴(yán)格驗證顯示，其線性檢測范圍覆蓋10-1000 pg/mL，靈敏度達(dá)到5 pg/mL，可穩(wěn)定識別天然和重組形式的TMEFF2蛋白?？蒲腥藛T可將其應(yīng)用于腫瘤微環(huán)境研究、疾病相關(guān)信號通路探索以及體外分子互作分析等領(lǐng)域，為探究TMEFF2在細(xì)胞增殖、分化及腫瘤轉(zhuǎn)移中的作用機(jī)制提供可靠工具，適用于細(xì)胞培養(yǎng)上清液、血清等生物樣本的定量檢測需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cancer/testis antigen family 120 member 2 antibody; CT120.2 antibody; HPP 1 antibody; HPP1 antibody; Hyperplastic polyposis protein 1 antibody; TEFF 2 antibody; TEFF2 antibody; TEFF2_HUMAN antibody; TENB 2 antibody; TENB2 antibody; TMEFF2 antibody; Tomoregulin antibody; Tomoregulin-2 antibody; TPEF antibody; TR 2 antibody; TR antibody; TR-2 antibody; Transmembrane protein containing epidermal growth factor and follistatin domains antibody; Transmembrane protein TENB2 antibody; Transmembrane protein with EGF like and two follistatin like domains 2 antibody; Transmembrane protein with EGF-like and two follistatin-like domains antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TMEFF2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG4(S228P)
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6G6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
  • 基因功能參考文獻(xiàn)：
    1. Differential TMEFF2 processing from a single transmembrane protein may be a general mechanism to modulate transmembrane protein levels and domains, dependent on the repertoire of ADAMs or TTSPs expressed by the target cell. PMID: 28762604
    2. TMEFF2 methylation is associated with clear cell renal cell carcinoma. PMID: 28128743
    3. Results suggest that TMEFF2 is a brain-enriched endogenous modulator of Abeta neurotoxicity and an enhancer of alpha-secretase processing of AbetaPP PMID: 26402097
    4. TMEFF2 regulates the non-canonical activin/BMP4 signaling, PI3K, and Ras/ERK1/2 pathways. PMID: 25573902
    5. c-Myc contributes to the epigenetic regulation of HPP1 via the dominant recruitment of HDAC3. PMID: 24919179
    6. TMEFF2 acts as a tumor suppressor in gastric cancer through direct interaction with SHP-1 and can be a potential biomarker of carcinogenesis. PMID: 24987055
    7. TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. PMID: 23824605
    8. Androgen signaling promotes eIF2alpha phosphorylation and subsequent translation of TMEFF2 via a mechanism that requires uORFs in the 5'-UTR of TMEFF2. PMID: 23405127
    9. Methylation of TMEFF2 gene is associated with colorectal neoplasia in ulcerative colitis and Crohn's colitis. PMID: 22532293
    10. Findings suggest that methylation-associated down-regulation of TMEFF2 gene may be involved in lung tumorigenesis and TMEFF2 methylation can serve as a specific blood-based biomarker for NSCLC. PMID: 22814847
    11. Several genes expressed at exceptionally high levels were identified associated with early oocyte development, TMEFF2, the Rho-GTPase-activating protein oligophrenin 1 (OPHN1) and the mitochondrial-encoded ATPase6 (ATP6). PMID: 22238370
    12. TMEFF2 can function to regulate PDGF signaling; it is hypermethylated and downregulated in glioma and several other cancers PMID: 21559523
    13. the tumor suppressor activity of TMEFF2 requires the cytoplasmic/transmembrane portion of the protein and correlates with its ability to bind to SARDH and to modulate the level of sarcosine. PMID: 21393249
    14. GDF15, HSPA2, TMEFF2, and VIM were identified as epigenetic biomarkers for Bladder cancer. PMID: 20975101
    15. Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. PMID: 12384516
    16. Aberrant methylation of the HPP1 gene is a relative common early event in ulcerative colitis-associated colorectal carcinoma. PMID: 12460892
    17. inverse correlation between TMEFF2 and c-Myc expression PMID: 12729735
    18. Hypermethylation of p16, RUNX3, and HPP1 in Barreett exophagus may represent independent risk factors for the progression of Barrett esophagus to esophageal cancer. PMID: 15824739
    19. A secreted form of TMEFF2 is expressed from TMEFF2 locus and may functionally interact with full-length TMEFF2, or its binding partners, and may also influence current immune-based treatment strategies PMID: 16439095
    20. Hypermethylation of HPP1 is associated with primary adenocarcinomas of the small bowel PMID: 16619216
    21. Methylation testing of fecal DNA using a panel of epigenetic markers (methylated SFRP2, HPP1 and MGMT) may be a simple and promising non-invasive screening method for colorectal carcinoma and precancerous lesions. PMID: 17352030
    22. TMEFF2 contributes to cell proliferation in an ADAM17-dependent autocrine fashion in cells expressing this protein PMID: 17942404
    23. data provides evidence to support the role of HPP1 as a tumor suppressor gene; activation of the STAT1 pathway likely represents the principal mediator of HPP1's tumor suppressive properties PMID: 18059030
    24. Methylated PAX6- or TPEF-promoters could represent biomarkers for bladder cancer. PMID: 18070176
    25. Distinct TPEF/HPP1 (transmembrane protein containing epidermal growth factor) gene methylation patterns in gastric cancer indicate a field effect in gastric carcinogenesis. PMID: 18799374
    26. promoter of TPEF gene is frequently hpermethylated, and associated with loss of TPEF mRNA expression in esophageal squamous cell carcinoma PMID: 19040536
    27. Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma. PMID: 19288010
    28. Analysis of DNA from peripheral blood revealed that TPEF methylation was detectable in colorectal tumor patients and patients with early or pre-neoplastic lesions, but not in healthy volunteers. PMID: 15068392

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  • 亞細(xì)胞定位：
    [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族：
    Tomoregulin family
  • 組織特異性：
    Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of nor
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11867

    OMIM: 605734

    KEGG: hsa:23671

    STRING: 9606.ENSP00000272771

    UniGene: Hs.144513