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  4. XPNPEP1 Recombinant Monoclonal Antibody

XPNPEP1 Recombinant Monoclonal Antibody

  • 中文名稱：
    XPNPEP1重組抗體
  • 貨號：
    CSB-RA878859MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA878859MA1HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing JK cells stained with CSB-RA878859MA1HU (red line) at 1:300. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,005 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA878859MA1HU XPNPEP1重組單克隆抗體是針對氨肽酶P（XPNPEP1）靶點開發(fā)的高特異性科研工具。該抗體通過重組技術(shù)制備，具有批次穩(wěn)定性和高親和力，經(jīng)ELISA、免疫組化（IHC）及流式細胞術(shù)（FC）多平臺驗證，在推薦稀釋比例范圍內(nèi)（IHC 1:20-1:200，F(xiàn)C 1:20-1:200）表現(xiàn)出優(yōu)異的目標蛋白結(jié)合能力。XPNPEP1作為細胞外基質(zhì)調(diào)節(jié)酶，參與血管緊張素、緩激肽等活性肽的代謝調(diào)控，在心血管穩(wěn)態(tài)和腎臟功能研究中具有重要價值。本產(chǎn)品適用于體外培養(yǎng)細胞或組織樣本中XPNPEP1的定位檢測及表達水平分析，可支持血管生物學、代謝性疾病機制、藥物靶點篩選等基礎(chǔ)研究領(lǐng)域。其單克隆特性確保實驗數(shù)據(jù)的高度可重復(fù)性，特別適用于需要長期追蹤蛋白動態(tài)變化的實驗體系，為探索XPNPEP1在細胞信號傳導(dǎo)及病理生理過程中的功能提供可靠工具。
  • Uniprot No.：
  • 基因名：
    XPNPEP1
  • 別名：
    Aminoacylproline aminopeptidase antibody; aminopeptidase P, cytosolic antibody; APP1 antibody; Cytosolic aminopeptidase P antibody; RP11 451M19.1 antibody; sAmp antibody; Soluble aminopeptidase P antibody; soluble antibody; X Pro aminopeptidase 1 antibody; X prolyl aminopeptidase (aminopeptidase P) 1 antibody; X prolyl aminopeptidase (Aminopeptidase P) 1 soluble antibody; X prolyl aminopeptidase 1 antibody; X prolyl aminopeptidase 1 soluble antibody; X-Pro aminopeptidase 1 antibody; X-prolyl aminopeptidase 1 antibody; Xaa Pro aminopeptidase 1 antibody; Xaa-Pro aminopeptidase 1 antibody; XPNPEP 1 antibody; XPNPEP antibody; xpnpep1 antibody; XPNPEPL antibody; XPNPEPL1 antibody; XPP1_HUMAN antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human XPNPEP1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4D12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    FC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
  • 基因功能參考文獻：
    1. Alanine replacement of Arg535 destabilizes the AMPP dimer and guanidine hydrochloride restores the native monomer-dimer equilibrium. It is proposed that Arg535 plays an important role in AMMP catalysis and in stabilization of the catalytically active dimeric state PMID: 29351301
    2. These data suggest that progesterone-induced increases in AP-P may contribute to the development of oral contraceptive pill-induced hypertension in susceptible Women. PMID: 19126663
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peptidase M24B family
  • 組織特異性：
    Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12822

    OMIM: 602443

    KEGG: hsa:7511

    STRING: 9606.ENSP00000421566

    UniGene: Hs.390623