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Histone H1.0 Recombinant Monoclonal Antibody

  • 中文名稱：
    組蛋白 H1.0重組抗體
  • 貨號：
    CSB-RA010087A0HU
  • 規(guī)格：
    ￥1320
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA010087A0HU 是一款針對核心連接組蛋白H1.0設(shè)計的高特異性科研抗體。該靶蛋白作為染色質(zhì)結(jié)構(gòu)的關(guān)鍵調(diào)控因子，通過參與核小體間連接維持基因組穩(wěn)定性，并在細(xì)胞分化、基因沉默及表觀遺傳調(diào)控中發(fā)揮重要作用。本產(chǎn)品經(jīng)ELISA平臺嚴(yán)格驗證，展現(xiàn)優(yōu)異的抗原結(jié)合能力與批次間一致性，可精準(zhǔn)識別天然構(gòu)象的Histone H1.0蛋白。其重組單克隆抗體技術(shù)確保低交叉反應(yīng)性和高重復(fù)性，適用于染色質(zhì)動態(tài)分析、表觀遺傳修飾研究、基因表達(dá)譜解析等基礎(chǔ)科研領(lǐng)域，尤其在探索細(xì)胞周期調(diào)控、干細(xì)胞分化機(jī)制及腫瘤發(fā)生相關(guān)染色質(zhì)重塑過程中具有重要應(yīng)用價值，為核蛋白功能研究和表觀遺傳學(xué)模型構(gòu)建提供可靠工具。
  • Uniprot No.：
  • 基因名：
    H1F0
  • 別名：
    H1 histone family member 0 antibody; H1(0) antibody; H10 antibody; H10_HUMAN antibody; h1f0 antibody; H1FV antibody; Histone H1'' antibody; Histone H1(0) antibody; Histone H1.0 antibody; Histone H10 antibody; Histone H5 antibody; MGC5241 antibody; N-terminally processed antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1C7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
  • 基因功能參考文獻(xiàn)：
    1. H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X. PMID: 27528617
    2. this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. PMID: 27708074
    3. The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c. PMID: 22334665
    4. nuclear transport of H1 histones requires a heterodimeric nuclear import receptor PMID: 12080050
    5. H1(0)histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression. PMID: 12149419

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
  • 蛋白家族：
    Histone H1/H5 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4714

    OMIM: 142708

    KEGG: hsa:3005

    STRING: 9606.ENSP00000344504

    UniGene: Hs.745024